Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066907588> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2066907588 endingPage "354" @default.
- W2066907588 startingPage "354" @default.
- W2066907588 abstract "Methylmalonic acid (MMA) in human serum is an important biomarker of methylmalonic acidemias. In this work, a simple and fast method based on microwave-assisted derivatization (MAD) followed by gas chromatography-mass spectrometry (GC-MS) was developed for the determination of methylmalonic acid in serum. In the proposed method, the MMA was extracted from serum and rapidly derivatized with bis(trimethylsilyl)trifluoroacetamide under microwave irradiation, finally the derivative was analyzed by GC-MS. The experimental parameters were investigated and the method validations were studied. The optimal conditions were obtained: 50 μL of bis(trimethylsilyl)trifluoroacetamide plus 1% trimethylchlorosilane (BSTFA-TMCS (99 : 1)) as derivatization regent, microwave power of 400 W and irradiation time of 2 min. The proposed method provided satisfactory precision (RSD 2.3–4.5%), wide linear range (0.021–5 mM), good linearity (R2 >0.999), and good recovery (96–101.3%). The proposed method was successfully applied to the analysis of MMA in serum samples. The experimental results showed that the proposed method was a simple, rapid, and efficient technique for the quantitative determination of MMA in serum." @default.
- W2066907588 created "2016-06-24" @default.
- W2066907588 creator A5003952549 @default.
- W2066907588 creator A5049879636 @default.
- W2066907588 creator A5063568462 @default.
- W2066907588 date "2010-01-01" @default.
- W2066907588 modified "2023-09-27" @default.
- W2066907588 title "Microwave-assisted derivatization for methylmalonic acid analysis in human serum by gas chromatography-mass spectrometry" @default.
- W2066907588 cites W1964818853 @default.
- W2066907588 cites W1966003931 @default.
- W2066907588 cites W1979482493 @default.
- W2066907588 cites W1982404969 @default.
- W2066907588 cites W1997061745 @default.
- W2066907588 cites W2007699205 @default.
- W2066907588 cites W2008308244 @default.
- W2066907588 cites W2036479201 @default.
- W2066907588 cites W2038834786 @default.
- W2066907588 cites W2046493938 @default.
- W2066907588 cites W2062804814 @default.
- W2066907588 cites W2086214546 @default.
- W2066907588 cites W2090769279 @default.
- W2066907588 cites W2112499399 @default.
- W2066907588 cites W2143397062 @default.
- W2066907588 cites W2149340056 @default.
- W2066907588 cites W2150829549 @default.
- W2066907588 cites W2165642651 @default.
- W2066907588 cites W2627040845 @default.
- W2066907588 doi "https://doi.org/10.1039/b9ay00289h" @default.
- W2066907588 hasPublicationYear "2010" @default.
- W2066907588 type Work @default.
- W2066907588 sameAs 2066907588 @default.
- W2066907588 citedByCount "3" @default.
- W2066907588 countsByYear W20669075882016 @default.
- W2066907588 countsByYear W20669075882019 @default.
- W2066907588 crossrefType "journal-article" @default.
- W2066907588 hasAuthorship W2066907588A5003952549 @default.
- W2066907588 hasAuthorship W2066907588A5049879636 @default.
- W2066907588 hasAuthorship W2066907588A5063568462 @default.
- W2066907588 hasConcept C119128265 @default.
- W2066907588 hasConcept C123460561 @default.
- W2066907588 hasConcept C162356407 @default.
- W2066907588 hasConcept C178790620 @default.
- W2066907588 hasConcept C185592680 @default.
- W2066907588 hasConcept C205345274 @default.
- W2066907588 hasConcept C2776209890 @default.
- W2066907588 hasConcept C2776923573 @default.
- W2066907588 hasConcept C2777000832 @default.
- W2066907588 hasConcept C2779750884 @default.
- W2066907588 hasConcept C2779821038 @default.
- W2066907588 hasConcept C43617362 @default.
- W2066907588 hasConcept C55493867 @default.
- W2066907588 hasConceptScore W2066907588C119128265 @default.
- W2066907588 hasConceptScore W2066907588C123460561 @default.
- W2066907588 hasConceptScore W2066907588C162356407 @default.
- W2066907588 hasConceptScore W2066907588C178790620 @default.
- W2066907588 hasConceptScore W2066907588C185592680 @default.
- W2066907588 hasConceptScore W2066907588C205345274 @default.
- W2066907588 hasConceptScore W2066907588C2776209890 @default.
- W2066907588 hasConceptScore W2066907588C2776923573 @default.
- W2066907588 hasConceptScore W2066907588C2777000832 @default.
- W2066907588 hasConceptScore W2066907588C2779750884 @default.
- W2066907588 hasConceptScore W2066907588C2779821038 @default.
- W2066907588 hasConceptScore W2066907588C43617362 @default.
- W2066907588 hasConceptScore W2066907588C55493867 @default.
- W2066907588 hasIssue "4" @default.
- W2066907588 hasLocation W20669075881 @default.
- W2066907588 hasOpenAccess W2066907588 @default.
- W2066907588 hasPrimaryLocation W20669075881 @default.
- W2066907588 hasRelatedWork W1970889696 @default.
- W2066907588 hasRelatedWork W2021585491 @default.
- W2066907588 hasRelatedWork W2027238251 @default.
- W2066907588 hasRelatedWork W2028935477 @default.
- W2066907588 hasRelatedWork W2047511728 @default.
- W2066907588 hasRelatedWork W2093181509 @default.
- W2066907588 hasRelatedWork W2168237453 @default.
- W2066907588 hasRelatedWork W2394771821 @default.
- W2066907588 hasRelatedWork W2508108370 @default.
- W2066907588 hasRelatedWork W3145758295 @default.
- W2066907588 hasVolume "2" @default.
- W2066907588 isParatext "false" @default.
- W2066907588 isRetracted "false" @default.
- W2066907588 magId "2066907588" @default.
- W2066907588 workType "article" @default.