Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066909520> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2066909520 endingPage "259" @default.
- W2066909520 startingPage "253" @default.
- W2066909520 abstract "Adherent human dermal fibroblasts secreted interleukin-6, prostaglandin E2, prostaglandin I2 and 15-hydroxyeicosatetraenoic acid (assayed by radioimmunoassay) during a 3 h incubation period. Although human dermal fibroblasts did not secrete interleukin-1α or interleukin-1β, human recombinant interleukin-1α stimulated arachidonic acid metabolism and interleukin-6 synthesis. This effect was, at least partly, dependent on de novo protein synthesis. In contrast, human recombinant interleukin-6 had no effect on the synthesis and release of the eicosanoids measured. Human recombinant interleukin-1α also stimulated the metabolism of [14C]arachidonic acid, but only if fibroblast were pre-incubated with the cytokine for three hours. Our data indicate that (a) fibroblasts secrete interleukin-6 but not inter-1, (b) interleukin-1α, but not interleukin-6, stimulates fibroblast arachidonic acid metabolism and (c) the mechanisms involved in the metabolism of endogenous arachidonic acid are more sensitive to human recombinant interleukin-1α than those involved in metabolism of the exogenous substrate." @default.
- W2066909520 created "2016-06-24" @default.
- W2066909520 creator A5020627800 @default.
- W2066909520 creator A5028864379 @default.
- W2066909520 creator A5055485342 @default.
- W2066909520 date "1992-04-01" @default.
- W2066909520 modified "2023-10-17" @default.
- W2066909520 title "Interleukin-1α-stimulated fibroblast eicosanid synthesis is not mediated by interleukin-6" @default.
- W2066909520 cites W1590259662 @default.
- W2066909520 cites W1965397525 @default.
- W2066909520 cites W1965525538 @default.
- W2066909520 cites W1968645000 @default.
- W2066909520 cites W1973446102 @default.
- W2066909520 cites W1976849443 @default.
- W2066909520 cites W1978404532 @default.
- W2066909520 cites W1996180410 @default.
- W2066909520 cites W1999632587 @default.
- W2066909520 cites W2020769348 @default.
- W2066909520 cites W2021310422 @default.
- W2066909520 cites W2032384189 @default.
- W2066909520 cites W2034953165 @default.
- W2066909520 cites W2070763971 @default.
- W2066909520 cites W2073499642 @default.
- W2066909520 cites W2084317513 @default.
- W2066909520 cites W2093204634 @default.
- W2066909520 cites W2106073768 @default.
- W2066909520 cites W2114634890 @default.
- W2066909520 cites W2125001573 @default.
- W2066909520 cites W2181517072 @default.
- W2066909520 cites W2324295814 @default.
- W2066909520 doi "https://doi.org/10.1016/0014-2999(92)90126-o" @default.
- W2066909520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1516641" @default.
- W2066909520 hasPublicationYear "1992" @default.
- W2066909520 type Work @default.
- W2066909520 sameAs 2066909520 @default.
- W2066909520 citedByCount "0" @default.
- W2066909520 crossrefType "journal-article" @default.
- W2066909520 hasAuthorship W2066909520A5020627800 @default.
- W2066909520 hasAuthorship W2066909520A5028864379 @default.
- W2066909520 hasAuthorship W2066909520A5055485342 @default.
- W2066909520 hasConcept C126322002 @default.
- W2066909520 hasConcept C134018914 @default.
- W2066909520 hasConcept C181199279 @default.
- W2066909520 hasConcept C185592680 @default.
- W2066909520 hasConcept C202751555 @default.
- W2066909520 hasConcept C203014093 @default.
- W2066909520 hasConcept C2777198256 @default.
- W2066909520 hasConcept C2777956040 @default.
- W2066909520 hasConcept C2778078955 @default.
- W2066909520 hasConcept C2778690821 @default.
- W2066909520 hasConcept C2780381497 @default.
- W2066909520 hasConcept C2780664492 @default.
- W2066909520 hasConcept C55493867 @default.
- W2066909520 hasConcept C71924100 @default.
- W2066909520 hasConcept C74172505 @default.
- W2066909520 hasConcept C86803240 @default.
- W2066909520 hasConceptScore W2066909520C126322002 @default.
- W2066909520 hasConceptScore W2066909520C134018914 @default.
- W2066909520 hasConceptScore W2066909520C181199279 @default.
- W2066909520 hasConceptScore W2066909520C185592680 @default.
- W2066909520 hasConceptScore W2066909520C202751555 @default.
- W2066909520 hasConceptScore W2066909520C203014093 @default.
- W2066909520 hasConceptScore W2066909520C2777198256 @default.
- W2066909520 hasConceptScore W2066909520C2777956040 @default.
- W2066909520 hasConceptScore W2066909520C2778078955 @default.
- W2066909520 hasConceptScore W2066909520C2778690821 @default.
- W2066909520 hasConceptScore W2066909520C2780381497 @default.
- W2066909520 hasConceptScore W2066909520C2780664492 @default.
- W2066909520 hasConceptScore W2066909520C55493867 @default.
- W2066909520 hasConceptScore W2066909520C71924100 @default.
- W2066909520 hasConceptScore W2066909520C74172505 @default.
- W2066909520 hasConceptScore W2066909520C86803240 @default.
- W2066909520 hasIssue "2-3" @default.
- W2066909520 hasLocation W20669095201 @default.
- W2066909520 hasLocation W20669095202 @default.
- W2066909520 hasOpenAccess W2066909520 @default.
- W2066909520 hasPrimaryLocation W20669095201 @default.
- W2066909520 hasRelatedWork W2002195623 @default.
- W2066909520 hasRelatedWork W2006844127 @default.
- W2066909520 hasRelatedWork W2010062539 @default.
- W2066909520 hasRelatedWork W2015899746 @default.
- W2066909520 hasRelatedWork W2016034363 @default.
- W2066909520 hasRelatedWork W2032572354 @default.
- W2066909520 hasRelatedWork W2050087369 @default.
- W2066909520 hasRelatedWork W2056100207 @default.
- W2066909520 hasRelatedWork W2113992931 @default.
- W2066909520 hasRelatedWork W2400401957 @default.
- W2066909520 hasVolume "214" @default.
- W2066909520 isParatext "false" @default.
- W2066909520 isRetracted "false" @default.
- W2066909520 magId "2066909520" @default.
- W2066909520 workType "article" @default.