FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066930190> ?p ?o ?g. }

• W2066930190 endingPage "499" @default.
• W2066930190 startingPage "494" @default.
• W2066930190 abstract "Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's sign. Treatment with a non-specific immunosuppressive agent or anti-inflammatory corticosteroids is beneficial, although some patients are resistant to these therapies. Proinflammatory cytokines derived from infiltrating inflammatory cells and activated resident cells within skin and muscle tissues likely promote chronic inflammation in DM pathogenesis; however, molecular mechanisms underlying the disease are not completely defined. Here we show that mRNA and protein levels of angiopoietin-like protein 2 (Angptl2), a recently identified chronic inflammation mediator, are abundant in keratinocytes from DM patients' skin eruptions. To examine whether skin cell-derived Angptl2 promotes DM manifestations, we analyzed transgenic (Tg) mice expressing Angptl2 driven by the keratinocyte specific promoter K14 (K14-Angptl2) and therefore constitutively expressing Angptl2 in skin tissue. We found that K14-Angptl2 Tg mice exhibited skin phenotypes similar to those observed in DM patients. In addition, treatment of keratinocytes with exogenous Angptl2 activated the NF-κB inflammatory cascade, resulting in increased expression of the proinflammatory cytokines IL-1β and IL-6. We propose that keratinocyte-derived Angptl2 functions in DM pathogenesis by inducing chronic inflammation in skin tissue." @default.
• W2066930190 created "2016-06-24" @default.
• W2066930190 creator A5003968607 @default.
• W2066930190 creator A5004693750 @default.
• W2066930190 creator A5009137874 @default.
• W2066930190 creator A5012764354 @default.
• W2066930190 creator A5021166647 @default.
• W2066930190 creator A5024769815 @default.
• W2066930190 creator A5057998844 @default.
• W2066930190 creator A5079630370 @default.
• W2066930190 creator A5079978258 @default.
• W2066930190 creator A5082891598 @default.
• W2066930190 creator A5087317062 @default.
• W2066930190 date "2012-02-01" @default.
• W2066930190 modified "2023-09-26" @default.
• W2066930190 title "The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis" @default.
• W2066930190 cites W1533021978 @default.
• W2066930190 cites W1855653050 @default.
• W2066930190 cites W1974975509 @default.
• W2066930190 cites W1985852439 @default.
• W2066930190 cites W1994867055 @default.
• W2066930190 cites W1995571382 @default.
• W2066930190 cites W2013679387 @default.
• W2066930190 cites W2043860203 @default.
• W2066930190 cites W2059419250 @default.
• W2066930190 cites W2073882423 @default.
• W2066930190 cites W2081455569 @default.
• W2066930190 cites W2086458733 @default.
• W2066930190 cites W2094833231 @default.
• W2066930190 cites W2094975067 @default.
• W2066930190 cites W2106590600 @default.
• W2066930190 cites W2118821808 @default.
• W2066930190 cites W2123105952 @default.
• W2066930190 cites W2126484151 @default.
• W2066930190 cites W2141696858 @default.
• W2066930190 cites W2165911231 @default.
• W2066930190 cites W2166098285 @default.
• W2066930190 cites W2314311014 @default.
• W2066930190 cites W2319202517 @default.
• W2066930190 cites W2405905128 @default.
• W2066930190 cites W3188869355 @default.
• W2066930190 cites W4211050134 @default.
• W2066930190 cites W4248767946 @default.
• W2066930190 doi "https://doi.org/10.1016/j.bbrc.2012.01.052" @default.
• W2066930190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22281496" @default.
• W2066930190 hasPublicationYear "2012" @default.
• W2066930190 type Work @default.
• W2066930190 sameAs 2066930190 @default.
• W2066930190 citedByCount "34" @default.
• W2066930190 countsByYear W20669301902012 @default.
• W2066930190 countsByYear W20669301902013 @default.
• W2066930190 countsByYear W20669301902014 @default.
• W2066930190 countsByYear W20669301902015 @default.
• W2066930190 countsByYear W20669301902016 @default.
• W2066930190 countsByYear W20669301902017 @default.
• W2066930190 countsByYear W20669301902018 @default.
• W2066930190 countsByYear W20669301902019 @default.
• W2066930190 countsByYear W20669301902020 @default.
• W2066930190 countsByYear W20669301902021 @default.
• W2066930190 countsByYear W20669301902023 @default.
• W2066930190 crossrefType "journal-article" @default.
• W2066930190 hasAuthorship W2066930190A5003968607 @default.
• W2066930190 hasAuthorship W2066930190A5004693750 @default.
• W2066930190 hasAuthorship W2066930190A5009137874 @default.
• W2066930190 hasAuthorship W2066930190A5012764354 @default.
• W2066930190 hasAuthorship W2066930190A5021166647 @default.
• W2066930190 hasAuthorship W2066930190A5024769815 @default.
• W2066930190 hasAuthorship W2066930190A5057998844 @default.
• W2066930190 hasAuthorship W2066930190A5079630370 @default.
• W2066930190 hasAuthorship W2066930190A5079978258 @default.
• W2066930190 hasAuthorship W2066930190A5082891598 @default.
• W2066930190 hasAuthorship W2066930190A5087317062 @default.
• W2066930190 hasConcept C142724271 @default.
• W2066930190 hasConcept C164027704 @default.
• W2066930190 hasConcept C203014093 @default.
• W2066930190 hasConcept C2776914184 @default.
• W2066930190 hasConcept C2777074287 @default.
• W2066930190 hasConcept C2778751314 @default.
• W2066930190 hasConcept C2780942790 @default.
• W2066930190 hasConcept C54355233 @default.
• W2066930190 hasConcept C71924100 @default.
• W2066930190 hasConcept C81885089 @default.
• W2066930190 hasConcept C86803240 @default.
• W2066930190 hasConceptScore W2066930190C142724271 @default.
• W2066930190 hasConceptScore W2066930190C164027704 @default.
• W2066930190 hasConceptScore W2066930190C203014093 @default.
• W2066930190 hasConceptScore W2066930190C2776914184 @default.
• W2066930190 hasConceptScore W2066930190C2777074287 @default.
• W2066930190 hasConceptScore W2066930190C2778751314 @default.
• W2066930190 hasConceptScore W2066930190C2780942790 @default.
• W2066930190 hasConceptScore W2066930190C54355233 @default.
• W2066930190 hasConceptScore W2066930190C71924100 @default.
• W2066930190 hasConceptScore W2066930190C81885089 @default.
• W2066930190 hasConceptScore W2066930190C86803240 @default.
• W2066930190 hasIssue "3" @default.
• W2066930190 hasLocation W20669301901 @default.
• W2066930190 hasLocation W20669301902 @default.
• W2066930190 hasOpenAccess W2066930190 @default.

• next