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- W2066934773 abstract "Abstract A variety of naphthalimide hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on the substituents on the aromatic moiety. The DNA-cleaving differences of these hydroperoxides may result from the differences of the intercalating ability of the naphthalene moiety. X-ray single crystal structure of a representative compound Fig. 1 , Fig. 2 , Scheme 1 Download : Download high-res image (28KB) Download : Download full-size image Fig. 1 . Light-induced cleavage of DNA by naphthalimide hydroperoxides. Supercoiled DNA runs at position I, nicked DNA at position II. pUC19 DNA (1.0 μg) was incubated in 10 μl of 1×TBE with drugs (400 μM concentration) at room temperature in the dark for 2 h, and irradiation for 30 min. The samples were analysed by gel electrophoresis in 1% agarose and the gel was stained with ethidium bromide. Lane 1: DNA control, Lane 2: 6, Lanes 3: 8, 4: 9:10≈1:1, 5: 12, 6: 1 Download : Download high-res image (62KB) Download : Download full-size image Fig. 2 . X-ray single crystal structure of 1 Download : Download high-res image (157KB) Download : Download full-size image Scheme 1 . was determined, and showed that all endocyclic atoms were coplanar, indicating a structural basis for potential and efficient DNA intercalation by Fig. 1 , Fig. 2 , Scheme 1 ." @default.
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- W2066934773 title "Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis" @default.
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