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• W2066935034 abstract "The receptor for parathyroid hormone (PTH) and PTH-related peptide (PTH1R) belongs to the class II G protein-coupled receptor superfamily. The calpain small subunit encoded by the gene Capns1 is the second protein and the first enzyme identified by a yeast two-hybrid screen using the intracellular C-terminal tail of the rat PTH1R. The calpain regulatory small subunit forms a heterodimer with the calpain large catalytic subunit and modulates various cellular functions as a cysteine protease. To investigate a physiological role of the calpain small subunit in cells of the osteoblast lineage, we generated osteoblast-specific Capns1 knockout mouse models and characterized their bone phenotype. Molecular mechanisms by which calpain modulates cell proliferation of the osteoblast lineage were further examined in vitro. Moreover, we utilized the mutant mice as a disease model of osteoporosis accompanied with impaired bone resorptive function and suggested a possible clinical translation of our basic research finding." @default.
• W2066935034 created "2016-06-24" @default.
• W2066935034 creator A5057996211 @default.
• W2066935034 date "2012-07-21" @default.
• W2066935034 modified "2023-09-26" @default.
• W2066935034 title "Overview of Calpain-Mediated Regulation of Bone and Fat Mass in Osteoblasts" @default.
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• W2066935034 doi "https://doi.org/10.1007/s12013-012-9393-7" @default.
• W2066935034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3525774" @default.
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• W2066935034 hasPublicationYear "2012" @default.
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