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- W2066935645 abstract "Higher-order chromatin structures appear to be dynamically arranged during development and differentiation. However, the molecular mechanism underlying their maintenance or disruption and their functional relevance in gene regulation are poorly understood. We recently described a dynamic long-range chromatin interaction between the gene-promoter of the cdk inhibitor p57kip2 and the imprinting control region KvDMR1 in muscle cells. Here we show that CTCF, the best characterized organizer of long-range chromatin interactions, binds to both p57kip2 promoter and KvDMR1 and is necessary for the maintenance of their physical contact. Moreover, we show that CTCF-mediated looping is required for preventing p57kip2 expression before differentiation. Finally, we provide evidence that the induction of p57kip2 during myogenesis involves the physical interaction of the muscle regulatory-factor MyoD with CTCF at KvDMR1, the displacement of the cohesin complex subunit Rad21 and the destabilization of the chromatin loop. The finding that MyoD affects chromatin looping at CTCF-binding sites represents the first evidence that a differentiation factor regulates chromatin loop dynamics and provides a useful paradigm for gaining insights into the developmental regulation of long-range chromatin contacts." @default.
- W2066935645 created "2016-06-24" @default.
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- W2066935645 date "2014-01-01" @default.
- W2066935645 modified "2023-10-16" @default.
- W2066935645 title "Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation" @default.
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- W2066935645 doi "https://doi.org/10.1242/jcs.149427" @default.
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