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- W2066952976 abstract "Lymphocyte and T-cell subpopulations were quantitated in 64 healthy, ambulatory adults, 33 women and 31 men, ranging in age from 22 to 83. Phytohemagglutinin (PHA) responsiveness was assessed simultaneously in 19 of these subjects and statistically correlated with T-cell subpopulations. B cells declined significantly in proportions and numbers with age (P < .0005) and this significance was maintained when men and women were separately considered. There was no significant change with age for males, females, or for the group as a whole when absolute and relative numbers of TG cells were statistically evaluated by regression analysis. An inverse correlation of percentages of TM cells with age was shown by regression analysis both in the entire sample (P < 0.00001) and when the sexes were separately considered (P < 0.01 in males; P < 0.005 in females). When absolute numbers of TM cells were evaluated by regression analysis significant decreases were found in the entire group (P < 0.005). However, this resulted primarily from changes in the male cohort as the P value for females was not significant. No correlation was found between PHA responsiveness and either the relative or absolute number of TG or TM cells." @default.
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- W2066952976 date "1980-02-01" @default.
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- W2066952976 title "Age-dependent changes in human peripheral blood B cells and T-cell subsets: Correlation with mitogen responsiveness" @default.
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- W2066952976 doi "https://doi.org/10.1016/0090-1229(80)90028-8" @default.
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