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• W2066960472 abstract "1. The effects of ouabain on renin secretion by rat renal cortical slices were studied. 2. Renin secretion was inhibited by 10(-3) M-ouabain in the presence of free Ca (10(-4) to 2.6 x 10(-3) M). Inhibition was blocked at Ca less than 10(-8) M. 3. The effect of free Ca on ouabain-inhibition was shown to be independent of the presence of EGTA, completely reversible, and unrelated to passive leakage of renin from non-viable cells, as assessed by simultaneous release of lactate dehydrogenase activity (LDH). 4. It is proposed that, as a result of inhibition of Na, K-ATPase by ouabain, (a) intracellular Na increases in the renin-secreting juxtaglomerular cells, (b) intracellular Ca increases, via an Na-Ca exchange mechanism, and (c) that Ca accumulation, in some unknown manner, inhibits renin secretion." @default.
• W2066960472 created "2016-06-24" @default.
• W2066960472 creator A5029212631 @default.
• W2066960472 date "1979-09-01" @default.
• W2066960472 modified "2023-10-16" @default.
• W2066960472 title "Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices." @default.
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• W2066960472 doi "https://doi.org/10.1113/jphysiol.1979.sp012919" @default.
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