Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066969710> ?p ?o ?g. }
- W2066969710 endingPage "1027" @default.
- W2066969710 startingPage "1015" @default.
- W2066969710 abstract "An important implication of the principle that metabolic energy is interconvertible with energy storable in electrochemical gradients is that the functions of channels, exchangers, pumps, and pathways are coupled and must coadapt. However, the inherent catalytic efficiencies of the three classes of proteins vary by orders of magnitude (channels > exchangers > pumps) while their inherent sensitivities to environmental perturbation often show the reverse sequence. Furthermore, recent studies of the structures and catalytic properties particularly of ion-specific channel and ion-specific pumps, in comparison with earlier studies of enzyme structures and functions, inidicate that not all parts of such multicomponent systems are equally plastic. Some components are highly constrained, some are moderately constrained, and some are extensively adaptable. Hence properties of the coupled system as a whole in any given tissue, organ, or species represent a compromise between what can and what cannot change. Natural selection appears to be forcing change and forcing constraint simultaneously and this duality is evident at all levels of structural organization and function." @default.
- W2066969710 created "2016-06-24" @default.
- W2066969710 creator A5025371676 @default.
- W2066969710 date "1988-05-01" @default.
- W2066969710 modified "2023-10-18" @default.
- W2066969710 title "Metabolic-, channel-, and pump-coupled functions: constraints and compromises of coadaptation" @default.
- W2066969710 cites W1443852999 @default.
- W2066969710 cites W1520927592 @default.
- W2066969710 cites W1543977144 @default.
- W2066969710 cites W1583519568 @default.
- W2066969710 cites W1600304436 @default.
- W2066969710 cites W178256505 @default.
- W2066969710 cites W1832842674 @default.
- W2066969710 cites W1887715315 @default.
- W2066969710 cites W1965147634 @default.
- W2066969710 cites W1974668954 @default.
- W2066969710 cites W1975645575 @default.
- W2066969710 cites W1977374570 @default.
- W2066969710 cites W1981357943 @default.
- W2066969710 cites W1984040687 @default.
- W2066969710 cites W1992261492 @default.
- W2066969710 cites W1993296661 @default.
- W2066969710 cites W1998217227 @default.
- W2066969710 cites W2008566929 @default.
- W2066969710 cites W2010353373 @default.
- W2066969710 cites W2020024927 @default.
- W2066969710 cites W2024640638 @default.
- W2066969710 cites W2027827482 @default.
- W2066969710 cites W2034692754 @default.
- W2066969710 cites W2036561380 @default.
- W2066969710 cites W2039427220 @default.
- W2066969710 cites W2042217106 @default.
- W2066969710 cites W2044267951 @default.
- W2066969710 cites W2049906118 @default.
- W2066969710 cites W2057119319 @default.
- W2066969710 cites W2057595921 @default.
- W2066969710 cites W2059737190 @default.
- W2066969710 cites W2070839508 @default.
- W2066969710 cites W2077233948 @default.
- W2066969710 cites W2078775477 @default.
- W2066969710 cites W2085139421 @default.
- W2066969710 cites W2086345475 @default.
- W2066969710 cites W2087135107 @default.
- W2066969710 cites W2088782754 @default.
- W2066969710 cites W2092984740 @default.
- W2066969710 cites W2120771179 @default.
- W2066969710 cites W2121977679 @default.
- W2066969710 cites W2128494612 @default.
- W2066969710 cites W2140930615 @default.
- W2066969710 cites W2141038649 @default.
- W2066969710 cites W2152021798 @default.
- W2066969710 cites W2167967321 @default.
- W2066969710 cites W2231682594 @default.
- W2066969710 cites W2291492716 @default.
- W2066969710 cites W2405137466 @default.
- W2066969710 cites W2414934670 @default.
- W2066969710 cites W2460242361 @default.
- W2066969710 cites W2463644909 @default.
- W2066969710 cites W33496744 @default.
- W2066969710 cites W44618918 @default.
- W2066969710 doi "https://doi.org/10.1139/z88-151" @default.
- W2066969710 hasPublicationYear "1988" @default.
- W2066969710 type Work @default.
- W2066969710 sameAs 2066969710 @default.
- W2066969710 citedByCount "29" @default.
- W2066969710 countsByYear W20669697102015 @default.
- W2066969710 countsByYear W20669697102018 @default.
- W2066969710 crossrefType "journal-article" @default.
- W2066969710 hasAuthorship W2066969710A5025371676 @default.
- W2066969710 hasConcept C121332964 @default.
- W2066969710 hasConcept C12554922 @default.
- W2066969710 hasConcept C127162648 @default.
- W2066969710 hasConcept C127413603 @default.
- W2066969710 hasConcept C134306372 @default.
- W2066969710 hasConcept C170493617 @default.
- W2066969710 hasConcept C177918212 @default.
- W2066969710 hasConcept C183696295 @default.
- W2066969710 hasConcept C186060115 @default.
- W2066969710 hasConcept C197115733 @default.
- W2066969710 hasConcept C2524010 @default.
- W2066969710 hasConcept C2776036281 @default.
- W2066969710 hasConcept C31258907 @default.
- W2066969710 hasConcept C33923547 @default.
- W2066969710 hasConcept C41008148 @default.
- W2066969710 hasConcept C50254741 @default.
- W2066969710 hasConcept C55493867 @default.
- W2066969710 hasConcept C62520636 @default.
- W2066969710 hasConcept C86803240 @default.
- W2066969710 hasConceptScore W2066969710C121332964 @default.
- W2066969710 hasConceptScore W2066969710C12554922 @default.
- W2066969710 hasConceptScore W2066969710C127162648 @default.
- W2066969710 hasConceptScore W2066969710C127413603 @default.
- W2066969710 hasConceptScore W2066969710C134306372 @default.
- W2066969710 hasConceptScore W2066969710C170493617 @default.
- W2066969710 hasConceptScore W2066969710C177918212 @default.
- W2066969710 hasConceptScore W2066969710C183696295 @default.
- W2066969710 hasConceptScore W2066969710C186060115 @default.
- W2066969710 hasConceptScore W2066969710C197115733 @default.