Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066970650> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2066970650 endingPage "14590" @default.
- W2066970650 startingPage "14587" @default.
- W2066970650 abstract "Accumulated evidence suggests that amyloid-β has a critical role in chronic neurodegenerative disorders such as Alzheimer’s disease. Therefore, understanding of amyloid-β fibrillization is a focus of interest for the development of innovative therapeutic and diagnostic applications. The fibrillization of amyloid-β has similar growth characteristics of polymeric nanoparticles and current monitoring methods show only qualitative or static information. Here we describe a noninvasive real-time monitoring of nanoscale amyloid-β fibrillization by simultaneous Dielectric Relaxation Spectroscopy (DRS) and label-free dark-field imaging. First, the hydrodynamic radius is characterized by DRS, which can reflect the averaged radius of fibrilized amyloid-β, and we observe an increase from 19 to 21 nm during 48 h. Scattering intensity from dark-field imaging allowed us to visualize and quantify the fibrillization with respect to the incubation time of amyloid-β. Consequently, real-time observation and quantification of changes in both hydrodynamic radii and optical properties (i.e., scattering intensity) were performed simultaneously. Such a dual-mode technique may prove valuable for elucidating the mechanism of amyloid fibrillization and ultimately for designing possible diagnostic methods." @default.
- W2066970650 created "2016-06-24" @default.
- W2066970650 creator A5041182419 @default.
- W2066970650 creator A5061975152 @default.
- W2066970650 creator A5073611697 @default.
- W2066970650 creator A5082741426 @default.
- W2066970650 date "2009-07-09" @default.
- W2066970650 modified "2023-09-26" @default.
- W2066970650 title "Noninvasive Real-time Monitoring of Amyloid-β Fibrillization via Simultaneous Label-free Dielectric Relaxation Spectroscopy and Dark-Field Imaging" @default.
- W2066970650 cites W1963805451 @default.
- W2066970650 cites W1973897761 @default.
- W2066970650 cites W1993050097 @default.
- W2066970650 cites W2002930710 @default.
- W2066970650 cites W2004098528 @default.
- W2066970650 cites W2014451295 @default.
- W2066970650 cites W2019212178 @default.
- W2066970650 cites W2025607001 @default.
- W2066970650 cites W2034885156 @default.
- W2066970650 cites W2050168961 @default.
- W2066970650 cites W2055961109 @default.
- W2066970650 cites W2058662097 @default.
- W2066970650 cites W2067214887 @default.
- W2066970650 cites W2082288645 @default.
- W2066970650 cites W2093942461 @default.
- W2066970650 cites W2096410114 @default.
- W2066970650 cites W2122294662 @default.
- W2066970650 cites W2125172857 @default.
- W2066970650 cites W2134909516 @default.
- W2066970650 cites W2135150574 @default.
- W2066970650 cites W2140797607 @default.
- W2066970650 cites W2162741488 @default.
- W2066970650 cites W2349463330 @default.
- W2066970650 doi "https://doi.org/10.1021/jp904157j" @default.
- W2066970650 hasPublicationYear "2009" @default.
- W2066970650 type Work @default.
- W2066970650 sameAs 2066970650 @default.
- W2066970650 citedByCount "4" @default.
- W2066970650 countsByYear W20669706502013 @default.
- W2066970650 countsByYear W20669706502014 @default.
- W2066970650 countsByYear W20669706502020 @default.
- W2066970650 crossrefType "journal-article" @default.
- W2066970650 hasAuthorship W2066970650A5041182419 @default.
- W2066970650 hasAuthorship W2066970650A5061975152 @default.
- W2066970650 hasAuthorship W2066970650A5073611697 @default.
- W2066970650 hasAuthorship W2066970650A5082741426 @default.
- W2066970650 hasConcept C12554922 @default.
- W2066970650 hasConcept C133386390 @default.
- W2066970650 hasConcept C169760540 @default.
- W2066970650 hasConcept C171250308 @default.
- W2066970650 hasConcept C179104552 @default.
- W2066970650 hasConcept C185592680 @default.
- W2066970650 hasConcept C192562407 @default.
- W2066970650 hasConcept C2776029896 @default.
- W2066970650 hasConcept C2777633098 @default.
- W2066970650 hasConcept C49040817 @default.
- W2066970650 hasConcept C86803240 @default.
- W2066970650 hasConceptScore W2066970650C12554922 @default.
- W2066970650 hasConceptScore W2066970650C133386390 @default.
- W2066970650 hasConceptScore W2066970650C169760540 @default.
- W2066970650 hasConceptScore W2066970650C171250308 @default.
- W2066970650 hasConceptScore W2066970650C179104552 @default.
- W2066970650 hasConceptScore W2066970650C185592680 @default.
- W2066970650 hasConceptScore W2066970650C192562407 @default.
- W2066970650 hasConceptScore W2066970650C2776029896 @default.
- W2066970650 hasConceptScore W2066970650C2777633098 @default.
- W2066970650 hasConceptScore W2066970650C49040817 @default.
- W2066970650 hasConceptScore W2066970650C86803240 @default.
- W2066970650 hasIssue "33" @default.
- W2066970650 hasLocation W20669706501 @default.
- W2066970650 hasOpenAccess W2066970650 @default.
- W2066970650 hasPrimaryLocation W20669706501 @default.
- W2066970650 hasRelatedWork W2053508813 @default.
- W2066970650 hasRelatedWork W2092872563 @default.
- W2066970650 hasRelatedWork W2102244574 @default.
- W2066970650 hasRelatedWork W2371468566 @default.
- W2066970650 hasRelatedWork W2374646600 @default.
- W2066970650 hasRelatedWork W2804544673 @default.
- W2066970650 hasRelatedWork W2863738027 @default.
- W2066970650 hasRelatedWork W2899084033 @default.
- W2066970650 hasRelatedWork W4252547859 @default.
- W2066970650 hasRelatedWork W4253731651 @default.
- W2066970650 hasVolume "113" @default.
- W2066970650 isParatext "false" @default.
- W2066970650 isRetracted "false" @default.
- W2066970650 magId "2066970650" @default.
- W2066970650 workType "article" @default.