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- W2066972150 endingPage "14672" @default.
- W2066972150 startingPage "14672" @default.
- W2066972150 abstract "Alcoholic fatty liver disease (AFLD), a potentially pathologic condition, can progress to steatohepatitis, fibrosis, and cirrhosis, leading to an increased probability of hepatic failure and death. Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form of nicotinamide adenine dinucleotide in hepatocytes; increasing hepatic sterol regulatory element-binding protein (SREBP)-1, plasminogen activator inhibitor (PAI)-1, and early growth response-1 activity; and decreasing hepatic peroxisome proliferator-activated receptor-α activity. Alcohol activates the innate immune system and induces an imbalance of the immune response, which is followed by activated Kupffer cell-derived tumor necrosis factor (TNF)-α overproduction, which is in turn responsible for the changes in the hepatic SREBP-1 and PAI-1 activity. Alcohol abuse promotes the migration of bone marrow-derived cells (BMDCs) to the liver and then reprograms TNF-α expression from BMDCs. Chronic alcohol intake triggers the sympathetic hyperactivity-activated hepatic stellate cell (HSC) feedback loop that in turn activates the HSCs, resulting in HSC-derived TNF-α overproduction. Carvedilol may block this feedback loop by suppressing sympathetic activity, which attenuates the progression of AFLD. Clinical studies evaluating combination therapy of carvedilol with a TNF-α inhibitor to treat patients with AFLD are warranted to prevent the development of alcoholic liver disease." @default.
- W2066972150 created "2016-06-24" @default.
- W2066972150 creator A5081717764 @default.
- W2066972150 date "2014-01-01" @default.
- W2066972150 modified "2023-09-30" @default.
- W2066972150 title "Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver" @default.
- W2066972150 cites W1492672801 @default.
- W2066972150 cites W1507879124 @default.
- W2066972150 cites W1566461421 @default.
- W2066972150 cites W1566540765 @default.
- W2066972150 cites W1567881416 @default.
- W2066972150 cites W1568259808 @default.
- W2066972150 cites W1574483226 @default.
- W2066972150 cites W1592749565 @default.
- W2066972150 cites W1595565189 @default.
- W2066972150 cites W1694905673 @default.
- W2066972150 cites W1775787040 @default.
- W2066972150 cites W1966064283 @default.
- W2066972150 cites W1967502002 @default.
- W2066972150 cites W1967964480 @default.
- W2066972150 cites W1970020574 @default.
- W2066972150 cites W1970930193 @default.
- W2066972150 cites W1974580919 @default.
- W2066972150 cites W1976849547 @default.
- W2066972150 cites W1977677463 @default.
- W2066972150 cites W1978045299 @default.
- W2066972150 cites W1978466826 @default.
- W2066972150 cites W1978774658 @default.
- W2066972150 cites W1979523405 @default.
- W2066972150 cites W1981248031 @default.
- W2066972150 cites W1982164601 @default.
- W2066972150 cites W1984615306 @default.
- W2066972150 cites W1986910407 @default.
- W2066972150 cites W1987607701 @default.
- W2066972150 cites W1987872200 @default.
- W2066972150 cites W1988613128 @default.
- W2066972150 cites W1990247687 @default.
- W2066972150 cites W1991004213 @default.
- W2066972150 cites W1992314135 @default.
- W2066972150 cites W1992864925 @default.
- W2066972150 cites W1993863503 @default.
- W2066972150 cites W1995501935 @default.
- W2066972150 cites W1997329503 @default.
- W2066972150 cites W1998388102 @default.
- W2066972150 cites W2000963707 @default.
- W2066972150 cites W2003877166 @default.
- W2066972150 cites W2004372194 @default.
- W2066972150 cites W2004523293 @default.
- W2066972150 cites W2011508078 @default.
- W2066972150 cites W2012193165 @default.
- W2066972150 cites W2015468214 @default.
- W2066972150 cites W2017851289 @default.
- W2066972150 cites W2020778772 @default.
- W2066972150 cites W2023719883 @default.
- W2066972150 cites W2024914546 @default.
- W2066972150 cites W2024991605 @default.
- W2066972150 cites W2026464825 @default.
- W2066972150 cites W2028649168 @default.
- W2066972150 cites W2029157767 @default.
- W2066972150 cites W2030936504 @default.
- W2066972150 cites W2032828063 @default.
- W2066972150 cites W2033522281 @default.
- W2066972150 cites W2034839254 @default.
- W2066972150 cites W2037038225 @default.
- W2066972150 cites W2038946905 @default.
- W2066972150 cites W2048180954 @default.
- W2066972150 cites W2049078677 @default.
- W2066972150 cites W2051130685 @default.
- W2066972150 cites W2052497750 @default.
- W2066972150 cites W2054232142 @default.
- W2066972150 cites W2055452745 @default.
- W2066972150 cites W2055750936 @default.
- W2066972150 cites W2058843590 @default.
- W2066972150 cites W2059211446 @default.
- W2066972150 cites W2060882242 @default.
- W2066972150 cites W2061852823 @default.
- W2066972150 cites W2062289338 @default.
- W2066972150 cites W2063271924 @default.
- W2066972150 cites W2063949300 @default.
- W2066972150 cites W2068636462 @default.
- W2066972150 cites W2068865401 @default.
- W2066972150 cites W2070375814 @default.
- W2066972150 cites W2071991978 @default.
- W2066972150 cites W2073659110 @default.
- W2066972150 cites W2076295447 @default.
- W2066972150 cites W2077159408 @default.
- W2066972150 cites W2078033902 @default.
- W2066972150 cites W2078600472 @default.
- W2066972150 cites W2079295499 @default.
- W2066972150 cites W2080325240 @default.
- W2066972150 cites W2082967998 @default.
- W2066972150 cites W2083650135 @default.
- W2066972150 cites W2087459059 @default.
- W2066972150 cites W2087781405 @default.
- W2066972150 cites W2091992630 @default.
- W2066972150 cites W2092973330 @default.
- W2066972150 cites W2094053196 @default.
- W2066972150 cites W2094702659 @default.