FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066977229> ?p ?o ?g. }

• W2066977229 endingPage "871" @default.
• W2066977229 startingPage "867" @default.
• W2066977229 abstract "Dystroglycan (DG) complex, composed of αDG and βDG, provides a link between the extracellular matrix (ECM) and cortical cytoskeleton. Although the proteolytic processing of βDG was reported in various physiological and pathological conditions, its exact mechanism remains unknown. In this study, we addressed this issue using the cell culture system of rat schwannoma cell line RT4. We found that the culture medium of RT4 cells was enriched with the protease activity that degrades the fusion protein construct of the extracellular domain of βDG specifically. This activity was suppressed by the inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9, but not by the inhibitors of MMP-1, MMP-3, MMP-8, and MMP-13. Zymography and RT-PCR analysis showed that RT4 cells secreted MMP-2 and MMP-9 into the culture medium. Finally, active MMP-2 and MMP-9 enzymes degraded the fusion protein construct of the extracellular domain of βDG. These results indicate (1) that RT4 cells secrete the protease activity that degrades the extracellular domain of βDG specifically and (2) that MMP-2 and MMP-9 may be involved in this process." @default.
• W2066977229 created "2016-06-24" @default.
• W2066977229 creator A5010523107 @default.
• W2066977229 creator A5023976469 @default.
• W2066977229 creator A5042537349 @default.
• W2066977229 creator A5052940866 @default.
• W2066977229 creator A5074335599 @default.
• W2066977229 creator A5076214241 @default.
• W2066977229 date "2006-06-01" @default.
• W2066977229 modified "2023-10-18" @default.
• W2066977229 title "Characterization of the protease activity that cleaves the extracellular domain of β-dystroglycan" @default.
• W2066977229 cites W1568920274 @default.
• W2066977229 cites W1575992755 @default.
• W2066977229 cites W1968666078 @default.
• W2066977229 cites W1969570221 @default.
• W2066977229 cites W1971286991 @default.
• W2066977229 cites W1977320698 @default.
• W2066977229 cites W1988449987 @default.
• W2066977229 cites W1992338919 @default.
• W2066977229 cites W1994787439 @default.
• W2066977229 cites W2004710976 @default.
• W2066977229 cites W2017691913 @default.
• W2066977229 cites W2023566097 @default.
• W2066977229 cites W2025136908 @default.
• W2066977229 cites W2032754875 @default.
• W2066977229 cites W2064178452 @default.
• W2066977229 cites W2067175433 @default.
• W2066977229 cites W2081752951 @default.
• W2066977229 cites W2082567416 @default.
• W2066977229 cites W2142383257 @default.
• W2066977229 cites W2154793195 @default.
• W2066977229 cites W2164209124 @default.
• W2066977229 cites W2165809424 @default.
• W2066977229 doi "https://doi.org/10.1016/j.bbrc.2006.05.004" @default.
• W2066977229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16701552" @default.
• W2066977229 hasPublicationYear "2006" @default.
• W2066977229 type Work @default.
• W2066977229 sameAs 2066977229 @default.
• W2066977229 citedByCount "34" @default.
• W2066977229 countsByYear W20669772292012 @default.
• W2066977229 countsByYear W20669772292013 @default.
• W2066977229 countsByYear W20669772292014 @default.
• W2066977229 countsByYear W20669772292015 @default.
• W2066977229 countsByYear W20669772292016 @default.
• W2066977229 countsByYear W20669772292017 @default.
• W2066977229 countsByYear W20669772292019 @default.
• W2066977229 crossrefType "journal-article" @default.
• W2066977229 hasAuthorship W2066977229A5010523107 @default.
• W2066977229 hasAuthorship W2066977229A5023976469 @default.
• W2066977229 hasAuthorship W2066977229A5042537349 @default.
• W2066977229 hasAuthorship W2066977229A5052940866 @default.
• W2066977229 hasAuthorship W2066977229A5074335599 @default.
• W2066977229 hasAuthorship W2066977229A5076214241 @default.
• W2066977229 hasConcept C104317684 @default.
• W2066977229 hasConcept C109523444 @default.
• W2066977229 hasConcept C123894998 @default.
• W2066977229 hasConcept C177430391 @default.
• W2066977229 hasConcept C181199279 @default.
• W2066977229 hasConcept C185592680 @default.
• W2066977229 hasConcept C189165786 @default.
• W2066977229 hasConcept C2776714187 @default.
• W2066977229 hasConcept C2778384963 @default.
• W2066977229 hasConcept C2779814568 @default.
• W2066977229 hasConcept C28406088 @default.
• W2066977229 hasConcept C40767141 @default.
• W2066977229 hasConcept C49039625 @default.
• W2066977229 hasConcept C54355233 @default.
• W2066977229 hasConcept C55493867 @default.
• W2066977229 hasConcept C55728118 @default.
• W2066977229 hasConcept C81885089 @default.
• W2066977229 hasConcept C86803240 @default.
• W2066977229 hasConcept C95444343 @default.
• W2066977229 hasConceptScore W2066977229C104317684 @default.
• W2066977229 hasConceptScore W2066977229C109523444 @default.
• W2066977229 hasConceptScore W2066977229C123894998 @default.
• W2066977229 hasConceptScore W2066977229C177430391 @default.
• W2066977229 hasConceptScore W2066977229C181199279 @default.
• W2066977229 hasConceptScore W2066977229C185592680 @default.
• W2066977229 hasConceptScore W2066977229C189165786 @default.
• W2066977229 hasConceptScore W2066977229C2776714187 @default.
• W2066977229 hasConceptScore W2066977229C2778384963 @default.
• W2066977229 hasConceptScore W2066977229C2779814568 @default.
• W2066977229 hasConceptScore W2066977229C28406088 @default.
• W2066977229 hasConceptScore W2066977229C40767141 @default.
• W2066977229 hasConceptScore W2066977229C49039625 @default.
• W2066977229 hasConceptScore W2066977229C54355233 @default.
• W2066977229 hasConceptScore W2066977229C55493867 @default.
• W2066977229 hasConceptScore W2066977229C55728118 @default.
• W2066977229 hasConceptScore W2066977229C81885089 @default.
• W2066977229 hasConceptScore W2066977229C86803240 @default.
• W2066977229 hasConceptScore W2066977229C95444343 @default.
• W2066977229 hasFunder F4320320912 @default.
• W2066977229 hasFunder F4320321945 @default.
• W2066977229 hasIssue "2" @default.
• W2066977229 hasLocation W20669772291 @default.
• W2066977229 hasLocation W20669772292 @default.
• W2066977229 hasOpenAccess W2066977229 @default.
• W2066977229 hasPrimaryLocation W20669772291 @default.

• next