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- W2066978770 abstract "Originally characterized as the calcium- and phospholipid-dependent protein kinases, the protein kinases C include at least eight separate isoforms, some of which are calcium-independent and all of which are highly enriched in brain. Of the calcium-independent isoforms, the delta subspecies of protein kinase C has the most restricted complement of lipid activators and substrate specificity, suggesting that it may have a unique role in cell signalling pathways. Using immunocytochemistry, we report that the distribution of protein kinase C-delta immunoreactivity in rat brain is also restricted, being present in all sensory systems. Moreover, it is found in alternating hierarchies of sensory pathways: in all sensory systems except auditory, it is found in first- and third-order neurons, while in the auditory system, it is found in second- and fourth-order neurons. Thalamocortical systems are intensely immunoreactive, including barrel fields of the rat parietal cortex. Outside of sensory systems, protein kinase C-delta is present in cerebellum within longitudinal stripes in Purkinje neurons, and in the caudate-putamen, it appears to be associated with the striosome (patch) compartment. In contrast to all other protein kinase C isoforms, protein kinase C-delta is absent from hippocampus. These findings suggest that protein kinase C-delta may have a unique role in signal transduction in the central nervous system (CNS), especially in sensory systems." @default.
- W2066978770 created "2016-06-24" @default.
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- W2066978770 date "1993-05-15" @default.
- W2066978770 modified "2023-09-26" @default.
- W2066978770 title "Protein kinase C-delta in rat brain: Association with sensory neuronal hierarchies" @default.
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- W2066978770 doi "https://doi.org/10.1002/cne.903310307" @default.
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