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- W2066981382 abstract "www.thelancet.com Vol 380 August 25, 2012 725 Submissions should be made via our electronic submission system at http://ees.elsevier.com/ thelancet/ rather than clopido grel. However, we wonder whether the advantage in the change from clopidogrel to prasugrel is limited to carriers of CYP2C19*2. The antiplatelet eff ect of prasugrel is more potent than that of clopidogrel, even in non-carriers of CYP2C19*2. In these non-carriers, other singlenucleotide polymorphisms (eg, ABCB1 3435C→T) might regulate the effi cacy of clopidogrel independently of CYP2C19 genotype. Owing to the design of Roberts and colleagues’ clinical trial, the value of genotyping by itself might have been overestimated. Roberts and colleagues should at least have assessed the eff ect of a change from clopidogrel to prasugrel in randomly selected non-carriers of CYP2C19*2. We would appreciate it if Roberts and colleagues could provide any additional data." @default.
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- W2066981382 date "2012-08-01" @default.
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- W2066981382 title "Pharmacogenetic guidance for antiplatelet treatment" @default.
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- W2066981382 doi "https://doi.org/10.1016/s0140-6736(12)61399-3" @default.
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