FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067000276> ?p ?o ?g. }

• W2067000276 endingPage "13025" @default.
• W2067000276 startingPage "13020" @default.
• W2067000276 abstract "Cohesin's Smc1 and Smc3 subunits form V-shaped heterodimers, the nucleotide binding domains (NBDs) of which bind the C- and N-terminal domains, respectively, of the α-kleisin subunit, forming a large tripartite ring within in which sister DNAs are entrapped, and thereby held together (sister chromatid cohesion). During replication, establishment of stable cohesion is dependent on Eco1-mediated acetylation of Smc3's NBD, which is thought to prevent dissociation of α-kleisin from Smc3, thereby locking shut a DNA exit gate. How Scc3 and Pds5, regulatory subunits bound to α-kleisin, regulate cohesion establishment and maintenance is poorly understood. We show here that by binding to α-kleisin adjacent to its Smc3 nucleotide binding N-terminal domain, Pds5 not only promotes cohesin's release from chromatin but also mediates de novo acetylation of Smc3 by Eco1 during S phase and subsequently prevents de-acetylation by the deacetylase Hos1/HDAC8. By first promoting cohesin's release from chromosomes and subsequently creating and guarding the chemical modification responsible for blocking release, Pds5 enables chromosomal cohesin to switch during S phase from a state of high turnover to one capable of tenaciously holding sister chromatids together for extended periods of time, a duality that has hitherto complicated analysis of this versatile cohesin subunit." @default.
• W2067000276 created "2016-06-24" @default.
• W2067000276 creator A5010311770 @default.
• W2067000276 creator A5025297651 @default.
• W2067000276 creator A5048304795 @default.
• W2067000276 creator A5050561573 @default.
• W2067000276 creator A5053197986 @default.
• W2067000276 creator A5084293804 @default.
• W2067000276 creator A5085946915 @default.
• W2067000276 date "2013-07-22" @default.
• W2067000276 modified "2023-10-06" @default.
• W2067000276 title "Pds5 promotes and protects cohesin acetylation" @default.
• W2067000276 cites W1965813899 @default.
• W2067000276 cites W1969497434 @default.
• W2067000276 cites W1972091887 @default.
• W2067000276 cites W1972307085 @default.
• W2067000276 cites W1972918915 @default.
• W2067000276 cites W1974930724 @default.
• W2067000276 cites W1976842433 @default.
• W2067000276 cites W1979162302 @default.
• W2067000276 cites W1979298341 @default.
• W2067000276 cites W1980639342 @default.
• W2067000276 cites W2001218098 @default.
• W2067000276 cites W2001704867 @default.
• W2067000276 cites W2003101935 @default.
• W2067000276 cites W2004304977 @default.
• W2067000276 cites W2013035015 @default.
• W2067000276 cites W2013136145 @default.
• W2067000276 cites W2014012985 @default.
• W2067000276 cites W2015957073 @default.
• W2067000276 cites W2019077723 @default.
• W2067000276 cites W2021859989 @default.
• W2067000276 cites W2027329763 @default.
• W2067000276 cites W2027351887 @default.
• W2067000276 cites W2036889051 @default.
• W2067000276 cites W2041182908 @default.
• W2067000276 cites W2042339569 @default.
• W2067000276 cites W2045710299 @default.
• W2067000276 cites W2048854522 @default.
• W2067000276 cites W2049586586 @default.
• W2067000276 cites W2063450668 @default.
• W2067000276 cites W2074728323 @default.
• W2067000276 cites W2083171162 @default.
• W2067000276 cites W2097201830 @default.
• W2067000276 cites W2099943527 @default.
• W2067000276 cites W2107554748 @default.
• W2067000276 cites W2109248504 @default.
• W2067000276 cites W2116045064 @default.
• W2067000276 cites W2121056577 @default.
• W2067000276 cites W2129462456 @default.
• W2067000276 cites W2131253587 @default.
• W2067000276 cites W2139114666 @default.
• W2067000276 cites W2152414953 @default.
• W2067000276 cites W2159270074 @default.
• W2067000276 cites W2159938983 @default.
• W2067000276 cites W2167218002 @default.
• W2067000276 doi "https://doi.org/10.1073/pnas.1306900110" @default.
• W2067000276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3740900" @default.
• W2067000276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23878248" @default.
• W2067000276 hasPublicationYear "2013" @default.
• W2067000276 type Work @default.
• W2067000276 sameAs 2067000276 @default.
• W2067000276 citedByCount "109" @default.
• W2067000276 countsByYear W20670002762013 @default.
• W2067000276 countsByYear W20670002762014 @default.
• W2067000276 countsByYear W20670002762015 @default.
• W2067000276 countsByYear W20670002762016 @default.
• W2067000276 countsByYear W20670002762017 @default.
• W2067000276 countsByYear W20670002762018 @default.
• W2067000276 countsByYear W20670002762019 @default.
• W2067000276 countsByYear W20670002762020 @default.
• W2067000276 countsByYear W20670002762021 @default.
• W2067000276 countsByYear W20670002762022 @default.
• W2067000276 countsByYear W20670002762023 @default.
• W2067000276 crossrefType "journal-article" @default.
• W2067000276 hasAuthorship W2067000276A5010311770 @default.
• W2067000276 hasAuthorship W2067000276A5025297651 @default.
• W2067000276 hasAuthorship W2067000276A5048304795 @default.
• W2067000276 hasAuthorship W2067000276A5050561573 @default.
• W2067000276 hasAuthorship W2067000276A5053197986 @default.
• W2067000276 hasAuthorship W2067000276A5084293804 @default.
• W2067000276 hasAuthorship W2067000276A5085946915 @default.
• W2067000276 hasBestOaLocation W20670002761 @default.
• W2067000276 hasConcept C104292427 @default.
• W2067000276 hasConcept C104317684 @default.
• W2067000276 hasConcept C115821613 @default.
• W2067000276 hasConcept C119157956 @default.
• W2067000276 hasConcept C136322937 @default.
• W2067000276 hasConcept C152369539 @default.
• W2067000276 hasConcept C2778354886 @default.
• W2067000276 hasConcept C30481170 @default.
• W2067000276 hasConcept C552990157 @default.
• W2067000276 hasConcept C55493867 @default.
• W2067000276 hasConcept C73397532 @default.
• W2067000276 hasConcept C83640560 @default.
• W2067000276 hasConcept C8502773 @default.
• W2067000276 hasConcept C86803240 @default.
• W2067000276 hasConcept C95444343 @default.

• next