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- W2067004562 abstract "The kinetics of glutamate concentration in the synaptic cleft is an important determinant of synaptic function. To elucidate peak concentration of glutamate released from a single vesicle in the cleft, spontaneous excitatory postsynaptic currents (sEPSCs) in Off-bipolar cells from the sliced newt retina were analyzed using whole-cell patch clamp recording and the computer simulation. The sEPSCs were blocked by an AMPA/kainate (KA) antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and prolonged by cyclothiazide. However, an N-methyl-d-aspartate (NMDA) antagonist, D-2-amino-5-phosphonopentanoic acid (D-AP5), was ineffective. These suggest that sEPSCs in Off-bipolar cells are mediated exclusively by AMPA/KA receptors. sEPSCs simulated by a detailed kinetic model of AMPA receptor best approximated the data, when peak glutamate concentration was 10 μM. Therefore, it was concluded that peak concentration of glutamate released from a single vesicle would be elevated to approximately 10 μM at the newt Off-bipolar dendrite." @default.
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- W2067004562 title "Characterization of spontaneous excitatory synaptic currents in newt retinal bipolar cells" @default.
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- W2067004562 doi "https://doi.org/10.1016/s0304-3940(99)00511-x" @default.
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