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• W2067029179 abstract "ObjectiveTo investigate the effects of tibolone co-administration with GnRH agonist treatment in terms of cognition, mood, and quality of life.DesignRandomized, controlled, single-blind, clinical trial.SettingDepartment of gynecology and obstetrics at a university in Italy.Patient(s)One hundred ten premenopausal women with symptomatic uterine leiomyomas.Intervention(s)Six months of treatment with leuprolide acetate depot (11.25 mg IM, every 3 mo) associated with either tibolone (2.5 mg/d orally; group A) or placebo (1 tablet per d; group B).Main Outcome Measure(s)At baseline and after 6 months of treatment, uterine and leiomyoma sizes, leiomyoma-related symptoms, climacteric-like symptoms, cognition, mood, and quality of life.Result(s)At study entry, no difference was detected between groups in any parameters assessed. After treatment, the leiomyoma-related symptoms were significantly reduced in both groups, without any statistically significant differences between them. The Kupperman Index was statistically significantly higher in group B in comparison with baseline and group A. The cognition scores were statistically significantly different in comparison with baseline in group B, whereas no change was observed in group A. After treatment, mood and quality of life were statistically significantly improved in both groups, even though the improvement was significantly higher in group A than in group B.Conclusion(s)Tibolone administration reverses the deleterious effect on cognition that is caused by leuprolide acetate depot and improves mood and quality of life in patients who receive GnRH agonist for symptomatic uterine leiomyomas. To investigate the effects of tibolone co-administration with GnRH agonist treatment in terms of cognition, mood, and quality of life. Randomized, controlled, single-blind, clinical trial. Department of gynecology and obstetrics at a university in Italy. One hundred ten premenopausal women with symptomatic uterine leiomyomas. Six months of treatment with leuprolide acetate depot (11.25 mg IM, every 3 mo) associated with either tibolone (2.5 mg/d orally; group A) or placebo (1 tablet per d; group B). At baseline and after 6 months of treatment, uterine and leiomyoma sizes, leiomyoma-related symptoms, climacteric-like symptoms, cognition, mood, and quality of life. At study entry, no difference was detected between groups in any parameters assessed. After treatment, the leiomyoma-related symptoms were significantly reduced in both groups, without any statistically significant differences between them. The Kupperman Index was statistically significantly higher in group B in comparison with baseline and group A. The cognition scores were statistically significantly different in comparison with baseline in group B, whereas no change was observed in group A. After treatment, mood and quality of life were statistically significantly improved in both groups, even though the improvement was significantly higher in group A than in group B. Tibolone administration reverses the deleterious effect on cognition that is caused by leuprolide acetate depot and improves mood and quality of life in patients who receive GnRH agonist for symptomatic uterine leiomyomas." @default.
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• W2067029179 date "2008-07-01" @default.
• W2067029179 modified "2023-09-25" @default.
• W2067029179 title "Tibolone reverses the cognitive effects caused by leuprolide acetate administration, improving mood and quality of life in patients with symptomatic uterine leiomyomas" @default.
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• W2067029179 doi "https://doi.org/10.1016/j.fertnstert.2007.05.061" @default.
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