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• W2067034870 abstract "Asthma is a chronic inflammation of the airways associated with recurrent symptoms that range from mild to debilitating. Interleukin-10 (IL-10) is a cytokine that displays pleiotropic effects in asthma and allergy.To determine whether polymorphisms of IL-10/IL-10R pathway contribute to asthma susceptibility in Egyptian children.The IL-10 (-1082G/A), IL-10R1 (G330R), and signal transducer and activator of transcription 3 (STAT3) rs2293452 single-nucleotide polymorphism (SNP) were genotyped in 110 atopic children with asthma, 110 non-atopic children with asthma, and 110 healthy children. Serum IL-10 and immunoglobulin E (IgE) levels were determined by enzyme-linked immunosorbent assay.A significant association was observed between the IL-10 polymorphism and asthma in both atopic (P = .03) and non-atopic asthma groups (P = .04). The genotype frequencies of IL-10R1 polymorphisms did not differ between all groups. We identified a significant association between STAT3 polymorphism and asthma susceptibility in atopic asthma (P < .001), whereas no such association was observed in the non-atopic asthma group (P = .9). No evidence of gene interactions was found.Polymorphisms of IL-10 and STAT3 may be useful as a new DNA-based diagnostic biomarker for identifying high-risk children susceptible to asthma." @default.
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• W2067034870 date "2011-06-01" @default.
• W2067034870 modified "2023-10-02" @default.
• W2067034870 title "Association between genes encoding components of the IL-10/IL-0 receptor pathway and asthma in children" @default.
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• W2067034870 doi "https://doi.org/10.1016/j.anai.2011.02.021" @default.
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