Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067038570> ?p ?o ?g. }
- W2067038570 endingPage "369" @default.
- W2067038570 startingPage "360" @default.
- W2067038570 abstract "Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs). Circulating FFAs provide the substrate for triacylglycerol formation in the liver, and may also be directly cytotoxic. Hepatocyte apoptosis is a key histologic feature of NAFLD, and correlates with progressive inflammation and fibrosis. The molecular pathways leading to hepatocyte apoptosis are not fully defined; however, recent studies suggest that FFA-induced apoptosis contributes to the pathogenesis of nonalcoholic steatohepatitis. FFAs directly engage the core apoptotic machinery by activating the proapoptotic protein Bax, in a c-jun N-terminal kinase-dependent manner. FFAs also activate the lysosomal pathway of cell death and regulate death receptor gene expression. The role of ER stress and oxidative stress in the pathogenesis of nonalcoholic steatohepatitis has also been described. Understanding the molecular mediators of liver injury should promote development of mechanism-based therapeutic interventions." @default.
- W2067038570 created "2016-06-24" @default.
- W2067038570 creator A5002077162 @default.
- W2067038570 creator A5004470985 @default.
- W2067038570 date "2008-10-27" @default.
- W2067038570 modified "2023-09-28" @default.
- W2067038570 title "Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease" @default.
- W2067038570 cites W1502813670 @default.
- W2067038570 cites W1823288226 @default.
- W2067038570 cites W1963632881 @default.
- W2067038570 cites W1967554392 @default.
- W2067038570 cites W1968872717 @default.
- W2067038570 cites W1968940692 @default.
- W2067038570 cites W1970305888 @default.
- W2067038570 cites W1970468997 @default.
- W2067038570 cites W1973539438 @default.
- W2067038570 cites W1974033843 @default.
- W2067038570 cites W1978878949 @default.
- W2067038570 cites W1980050556 @default.
- W2067038570 cites W1982542439 @default.
- W2067038570 cites W1984077928 @default.
- W2067038570 cites W1985592156 @default.
- W2067038570 cites W1986568749 @default.
- W2067038570 cites W1997613978 @default.
- W2067038570 cites W2000054651 @default.
- W2067038570 cites W2000601548 @default.
- W2067038570 cites W2001987544 @default.
- W2067038570 cites W2003578093 @default.
- W2067038570 cites W2006516019 @default.
- W2067038570 cites W2007078899 @default.
- W2067038570 cites W2008869160 @default.
- W2067038570 cites W2010381644 @default.
- W2067038570 cites W2013813851 @default.
- W2067038570 cites W2015015357 @default.
- W2067038570 cites W2020242068 @default.
- W2067038570 cites W2020468088 @default.
- W2067038570 cites W2021051229 @default.
- W2067038570 cites W2022598304 @default.
- W2067038570 cites W2025607561 @default.
- W2067038570 cites W2029580279 @default.
- W2067038570 cites W2030337339 @default.
- W2067038570 cites W2030901818 @default.
- W2067038570 cites W2034188379 @default.
- W2067038570 cites W2034209605 @default.
- W2067038570 cites W2037591273 @default.
- W2067038570 cites W2038018821 @default.
- W2067038570 cites W2038148035 @default.
- W2067038570 cites W2041836907 @default.
- W2067038570 cites W2042555983 @default.
- W2067038570 cites W2046593056 @default.
- W2067038570 cites W2052045228 @default.
- W2067038570 cites W2052378749 @default.
- W2067038570 cites W2052663490 @default.
- W2067038570 cites W2054746523 @default.
- W2067038570 cites W2055355179 @default.
- W2067038570 cites W2058709707 @default.
- W2067038570 cites W2070053386 @default.
- W2067038570 cites W2071596637 @default.
- W2067038570 cites W2076633494 @default.
- W2067038570 cites W2081828123 @default.
- W2067038570 cites W2086082391 @default.
- W2067038570 cites W2088366586 @default.
- W2067038570 cites W2089198803 @default.
- W2067038570 cites W2091337145 @default.
- W2067038570 cites W2092412521 @default.
- W2067038570 cites W2092711814 @default.
- W2067038570 cites W2093308509 @default.
- W2067038570 cites W2093557429 @default.
- W2067038570 cites W2093824918 @default.
- W2067038570 cites W2095659152 @default.
- W2067038570 cites W2098518710 @default.
- W2067038570 cites W2099536385 @default.
- W2067038570 cites W2101380004 @default.
- W2067038570 cites W2103843518 @default.
- W2067038570 cites W2105448220 @default.
- W2067038570 cites W2105651504 @default.
- W2067038570 cites W2108678340 @default.
- W2067038570 cites W2108733091 @default.
- W2067038570 cites W2112038959 @default.
- W2067038570 cites W2118338384 @default.
- W2067038570 cites W2118912353 @default.
- W2067038570 cites W2126610675 @default.
- W2067038570 cites W2127039193 @default.
- W2067038570 cites W2128057304 @default.
- W2067038570 cites W2129125398 @default.
- W2067038570 cites W2138072361 @default.
- W2067038570 cites W2138485536 @default.
- W2067038570 cites W2140187466 @default.
- W2067038570 cites W2152385965 @default.
- W2067038570 cites W2156280702 @default.
- W2067038570 cites W2162051951 @default.
- W2067038570 cites W2168898273 @default.
- W2067038570 cites W2169460547 @default.
- W2067038570 cites W2169598496 @default.
- W2067038570 cites W2192080449 @default.
- W2067038570 cites W2738996050 @default.
- W2067038570 doi "https://doi.org/10.1055/s-0028-1091980" @default.
- W2067038570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2908270" @default.