FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067039219> ?p ?o ?g. }

• W2067039219 endingPage "1869" @default.
• W2067039219 startingPage "1862" @default.
• W2067039219 abstract "Identification of novel tumor-associated antigens (TAA) capable of eliciting T-cell responses has renewed interest in the development of anti-tumor vaccines. The insertion of genes encoding specific TAA into a vaccinia virus (rVV) is one approach to vaccination since large amounts of foreign DNA can be stably integrated into the poxvirus genome. Recent reports have documented an increased therapeutic effectiveness of poxvirus-based vaccines when additional treatment with cytokines, such as interleukin-2 (IL-2) or interleukin-12 (IL-12) were used, but the combination of these cytokines as adjuvants for a rVV encoding TAA have not been previously reported. The combination of IL-2 and IL-12 at single regimen systemic doses was toxic and sometimes fatal, manifesting largely as segmental epithelial apoptosis of the large bowel. To explore the local delivery of both cytokines to the site of vaccination, the genes encoding IL-2 and IL-12 were inserted into vaccinia virus along with a model tumor antigen gene. This construct contained five heterologous genes: LacZ (the model antigen), gpt (reporter gene), IL-2, and the two IL-12 subunit genes (p35 and p40). Treatment with this recombinant virus resulted in a reduced number of pulmonary metastases, improved survival, and minimal toxicity in a murine tumor model. The use of vaccinia virus for the insertion of other heterologous gene combinations may provide a powerful and less toxic approach for novel vaccination strategies in the treatment and prevention of cancer." @default.
• W2067039219 created "2016-06-24" @default.
• W2067039219 creator A5000946009 @default.
• W2067039219 creator A5062173516 @default.
• W2067039219 creator A5073786910 @default.
• W2067039219 creator A5083677583 @default.
• W2067039219 creator A5090739964 @default.
• W2067039219 date "2002-03-01" @default.
• W2067039219 modified "2023-10-05" @default.
• W2067039219 title "Insertion of interleukin-2 (IL-2) and interleukin-12 (IL-12) genes into vaccinia virus results in effective anti-tumor responses without toxicity" @default.
• W2067039219 cites W1489827712 @default.
• W2067039219 cites W1551774211 @default.
• W2067039219 cites W1561485846 @default.
• W2067039219 cites W1574264971 @default.
• W2067039219 cites W1617786219 @default.
• W2067039219 cites W1907524022 @default.
• W2067039219 cites W1945740511 @default.
• W2067039219 cites W1950572133 @default.
• W2067039219 cites W1960833366 @default.
• W2067039219 cites W1963950570 @default.
• W2067039219 cites W1984034322 @default.
• W2067039219 cites W1986046751 @default.
• W2067039219 cites W2009238488 @default.
• W2067039219 cites W2015843087 @default.
• W2067039219 cites W2017855555 @default.
• W2067039219 cites W2025270796 @default.
• W2067039219 cites W2034747114 @default.
• W2067039219 cites W2053148124 @default.
• W2067039219 cites W2053508680 @default.
• W2067039219 cites W2053967656 @default.
• W2067039219 cites W2054161891 @default.
• W2067039219 cites W2054167475 @default.
• W2067039219 cites W2059471808 @default.
• W2067039219 cites W2063800314 @default.
• W2067039219 cites W2067976882 @default.
• W2067039219 cites W2069705273 @default.
• W2067039219 cites W2080839791 @default.
• W2067039219 cites W2091285469 @default.
• W2067039219 cites W2102156468 @default.
• W2067039219 cites W2140330161 @default.
• W2067039219 cites W2141547837 @default.
• W2067039219 cites W2142066580 @default.
• W2067039219 cites W2151707711 @default.
• W2067039219 cites W2163772432 @default.
• W2067039219 cites W2335365056 @default.
• W2067039219 cites W2345229587 @default.
• W2067039219 cites W4250497858 @default.
• W2067039219 doi "https://doi.org/10.1016/s0264-410x(02)00032-4" @default.
• W2067039219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11906776" @default.
• W2067039219 hasPublicationYear "2002" @default.
• W2067039219 type Work @default.
• W2067039219 sameAs 2067039219 @default.
• W2067039219 citedByCount "47" @default.
• W2067039219 countsByYear W20670392192012 @default.
• W2067039219 countsByYear W20670392192013 @default.
• W2067039219 countsByYear W20670392192014 @default.
• W2067039219 countsByYear W20670392192015 @default.
• W2067039219 countsByYear W20670392192016 @default.
• W2067039219 countsByYear W20670392192017 @default.
• W2067039219 countsByYear W20670392192018 @default.
• W2067039219 countsByYear W20670392192019 @default.
• W2067039219 countsByYear W20670392192020 @default.
• W2067039219 countsByYear W20670392192021 @default.
• W2067039219 countsByYear W20670392192022 @default.
• W2067039219 countsByYear W20670392192023 @default.
• W2067039219 crossrefType "journal-article" @default.
• W2067039219 hasAuthorship W2067039219A5000946009 @default.
• W2067039219 hasAuthorship W2067039219A5062173516 @default.
• W2067039219 hasAuthorship W2067039219A5073786910 @default.
• W2067039219 hasAuthorship W2067039219A5083677583 @default.
• W2067039219 hasAuthorship W2067039219A5090739964 @default.
• W2067039219 hasConcept C104317684 @default.
• W2067039219 hasConcept C111599444 @default.
• W2067039219 hasConcept C159047783 @default.
• W2067039219 hasConcept C203014093 @default.
• W2067039219 hasConcept C22070199 @default.
• W2067039219 hasConcept C2522874641 @default.
• W2067039219 hasConcept C2777371288 @default.
• W2067039219 hasConcept C2779094796 @default.
• W2067039219 hasConcept C2779827044 @default.
• W2067039219 hasConcept C2780115692 @default.
• W2067039219 hasConcept C2781356689 @default.
• W2067039219 hasConcept C39060996 @default.
• W2067039219 hasConcept C40767141 @default.
• W2067039219 hasConcept C54355233 @default.
• W2067039219 hasConcept C86803240 @default.
• W2067039219 hasConcept C8891405 @default.
• W2067039219 hasConceptScore W2067039219C104317684 @default.
• W2067039219 hasConceptScore W2067039219C111599444 @default.
• W2067039219 hasConceptScore W2067039219C159047783 @default.
• W2067039219 hasConceptScore W2067039219C203014093 @default.
• W2067039219 hasConceptScore W2067039219C22070199 @default.
• W2067039219 hasConceptScore W2067039219C2522874641 @default.
• W2067039219 hasConceptScore W2067039219C2777371288 @default.
• W2067039219 hasConceptScore W2067039219C2779094796 @default.
• W2067039219 hasConceptScore W2067039219C2779827044 @default.
• W2067039219 hasConceptScore W2067039219C2780115692 @default.
• W2067039219 hasConceptScore W2067039219C2781356689 @default.

• next