Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067047257> ?p ?o ?g. }
- W2067047257 endingPage "973" @default.
- W2067047257 startingPage "969" @default.
- W2067047257 abstract "The non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has been shown to produce cognitive deficits. However, the effects of ketamine on the consolidation phase of memory remain poorly characterized. Here we show that systemic administration of ketamine immediately after training dose-dependently impairs long-term retention of memory for a novel object recognition (NOR) task in rats. Control experiments showed that the impairing effects of ketamine could not be attributed to an influence on memory retrieval or sensorimotor effects. In addition, ketamine prevented the increase in hippocampal brain-derived neurotrophic factor (BDNF) levels induced by NOR learning. Our results show for the first time that ketamine disrupts the consolidation phase of long-term recognition memory. In addition, the findings suggest that the amnestic effects of ketamine might be at least partially mediated by an influence on BDNF signaling in the hippocampus." @default.
- W2067047257 created "2016-06-24" @default.
- W2067047257 creator A5030085949 @default.
- W2067047257 creator A5034971594 @default.
- W2067047257 creator A5039912886 @default.
- W2067047257 creator A5049910468 @default.
- W2067047257 creator A5066511141 @default.
- W2067047257 creator A5068512037 @default.
- W2067047257 creator A5076334811 @default.
- W2067047257 creator A5082809192 @default.
- W2067047257 creator A5088796278 @default.
- W2067047257 date "2010-06-01" @default.
- W2067047257 modified "2023-10-01" @default.
- W2067047257 title "Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels" @default.
- W2067047257 cites W1481984979 @default.
- W2067047257 cites W1484497860 @default.
- W2067047257 cites W1589353809 @default.
- W2067047257 cites W1968195648 @default.
- W2067047257 cites W1972880019 @default.
- W2067047257 cites W1986503634 @default.
- W2067047257 cites W2018457415 @default.
- W2067047257 cites W2024636695 @default.
- W2067047257 cites W2028531603 @default.
- W2067047257 cites W2029925498 @default.
- W2067047257 cites W2038130139 @default.
- W2067047257 cites W2042129379 @default.
- W2067047257 cites W2047731623 @default.
- W2067047257 cites W2054675346 @default.
- W2067047257 cites W2055667548 @default.
- W2067047257 cites W2062991954 @default.
- W2067047257 cites W2063337155 @default.
- W2067047257 cites W2076818546 @default.
- W2067047257 cites W2083631240 @default.
- W2067047257 cites W2094395658 @default.
- W2067047257 cites W2094491891 @default.
- W2067047257 cites W2096808564 @default.
- W2067047257 cites W2127455950 @default.
- W2067047257 cites W2132662023 @default.
- W2067047257 cites W2144423934 @default.
- W2067047257 cites W2149954813 @default.
- W2067047257 cites W2151288150 @default.
- W2067047257 cites W3192761376 @default.
- W2067047257 cites W4247614046 @default.
- W2067047257 doi "https://doi.org/10.1016/j.neuroscience.2010.03.032" @default.
- W2067047257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20338225" @default.
- W2067047257 hasPublicationYear "2010" @default.
- W2067047257 type Work @default.
- W2067047257 sameAs 2067047257 @default.
- W2067047257 citedByCount "115" @default.
- W2067047257 countsByYear W20670472572012 @default.
- W2067047257 countsByYear W20670472572013 @default.
- W2067047257 countsByYear W20670472572014 @default.
- W2067047257 countsByYear W20670472572015 @default.
- W2067047257 countsByYear W20670472572016 @default.
- W2067047257 countsByYear W20670472572017 @default.
- W2067047257 countsByYear W20670472572018 @default.
- W2067047257 countsByYear W20670472572019 @default.
- W2067047257 countsByYear W20670472572020 @default.
- W2067047257 countsByYear W20670472572021 @default.
- W2067047257 countsByYear W20670472572022 @default.
- W2067047257 countsByYear W20670472572023 @default.
- W2067047257 crossrefType "journal-article" @default.
- W2067047257 hasAuthorship W2067047257A5030085949 @default.
- W2067047257 hasAuthorship W2067047257A5034971594 @default.
- W2067047257 hasAuthorship W2067047257A5039912886 @default.
- W2067047257 hasAuthorship W2067047257A5049910468 @default.
- W2067047257 hasAuthorship W2067047257A5066511141 @default.
- W2067047257 hasAuthorship W2067047257A5068512037 @default.
- W2067047257 hasAuthorship W2067047257A5076334811 @default.
- W2067047257 hasAuthorship W2067047257A5082809192 @default.
- W2067047257 hasAuthorship W2067047257A5088796278 @default.
- W2067047257 hasConcept C126322002 @default.
- W2067047257 hasConcept C148762608 @default.
- W2067047257 hasConcept C15744967 @default.
- W2067047257 hasConcept C160539049 @default.
- W2067047257 hasConcept C169760540 @default.
- W2067047257 hasConcept C169900460 @default.
- W2067047257 hasConcept C170493617 @default.
- W2067047257 hasConcept C2776885963 @default.
- W2067047257 hasConcept C2778790584 @default.
- W2067047257 hasConcept C2780795376 @default.
- W2067047257 hasConcept C2781161787 @default.
- W2067047257 hasConcept C48455012 @default.
- W2067047257 hasConcept C61174792 @default.
- W2067047257 hasConcept C67018056 @default.
- W2067047257 hasConcept C71924100 @default.
- W2067047257 hasConcept C90269970 @default.
- W2067047257 hasConceptScore W2067047257C126322002 @default.
- W2067047257 hasConceptScore W2067047257C148762608 @default.
- W2067047257 hasConceptScore W2067047257C15744967 @default.
- W2067047257 hasConceptScore W2067047257C160539049 @default.
- W2067047257 hasConceptScore W2067047257C169760540 @default.
- W2067047257 hasConceptScore W2067047257C169900460 @default.
- W2067047257 hasConceptScore W2067047257C170493617 @default.
- W2067047257 hasConceptScore W2067047257C2776885963 @default.
- W2067047257 hasConceptScore W2067047257C2778790584 @default.
- W2067047257 hasConceptScore W2067047257C2780795376 @default.
- W2067047257 hasConceptScore W2067047257C2781161787 @default.