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- W2067067873 abstract "Reaction of o -azidobenzenesulfonamides with ethyl carbonochloridate afforded the corresponding amide derivatives, which gave 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides through an intramolecular aza-Wittig reaction. The reaction was found to be general through the synthesis of a number of benzothiadiazine 1,1-dioxides. Acid-catalyzed hydrolysis of 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides furnished the 2-substituted benzothiadiazine-3-one 1,1-dioxides in good yields and high purity, which is the core moiety of RSV inhibitors." @default.
- W2067067873 created "2016-06-24" @default.
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- W2067067873 date "2013-03-08" @default.
- W2067067873 modified "2023-10-02" @default.
- W2067067873 title "Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction" @default.
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- W2067067873 doi "https://doi.org/10.3762/bjoc.9.54" @default.
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