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• W2067093997 abstract "Intensity modulated radiotherapy (IMRT) is arguably a European invention. The pivotal paper in the conceptual evolution of IMRT is the 1982 paper by Anders Brahme and colleagues [ [15] Brahme A. Roos J.E. Lax I. Solution of an integral equation encountered in rotation therapy. Phys Med Biol. 1982; 27: 1221-1229 Crossref PubMed Scopus (249) Google Scholar ] where they showed that a donut shaped dose distribution with blocking of the central volume could be delivered by a rotating beam with a non-uniform fluence profile. By 1988 the Stockholm group had developed an algorithm that allowed—at least in principle—the inverse planning of a specified dose distribution by a method quite similar to image reconstruction by back projection in computed tomography [ [14] Brahme A. Optimization of stationary and moving beam radiation therapy techniques. Radiother Oncol. 1988; 12: 129-140 Abstract Full Text PDF PubMed Scopus (399) Google Scholar ]. Other important early contributions were made by Niels Ulsø in Aarhus [ [42] Shah H.K. Tome W. Bentzen S.M. et al. Evolution in H&N IMRT practice and early assessment of outcome at a single academic center. Int J Radiat Oncol Biol Phys. 2005; 63: S360-S361 Abstract Full Text Full Text PDF Google Scholar ], Steve Webb in London [ [49] Webb S. Optimisation of conformal radiotherapy dose distributions by simulated annealing. Phys Med Biol. 1989; 34: 1349-1370 Crossref PubMed Scopus (321) Google Scholar ], Thomas Bortfeld and Wolfgang Schlegel in Heidelberg [ [11] Bortfeld T. Burkelbach J. Boesecke R. Schlegel W. Methods of image reconstruction from projections applied to conformation radiotherapy. Phys Med Biol. 1990; 35: 1423-1434 Crossref PubMed Scopus (331) Google Scholar ]. For an interesting and quite detailed discussion of the conceptual development of IMRT, the reader is referred to the recent review by Webb [ [50] Webb S. The physical basis of IMRT and inverse planning. Br J Radiol. 2003; 76: 678-689 Crossref PubMed Scopus (202) Google Scholar ]." @default.
• W2067093997 created "2016-06-24" @default.
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• W2067093997 date "2005-12-01" @default.
• W2067093997 modified "2023-09-27" @default.
• W2067093997 title "Radiation therapy: Intensity modulated, image guided, biologically optimized and evidence based" @default.
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• W2067093997 doi "https://doi.org/10.1016/j.radonc.2005.11.001" @default.
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