FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067094952> ?p ?o ?g. }

• W2067094952 endingPage "915" @default.
• W2067094952 startingPage "908" @default.
• W2067094952 abstract "In 138 oligo-amenorrheic white women with polycystic ovary syndrome (PCOS) (31 ± 9-years-old), our first specific aim was to assess the incidence of the metabolic syndrome and to compare metabolic syndrome abnormalities in women with PCOS to those in the National Health and Nutrition Examination Survey (NHANES) III cohort of 1,887 white women. Our second aim was to determine whether metformin (2.55 g/d) and a diet of 1,500 calories, 26% protein, 44% carbohydrate (42% of carbohydrate complex), 30% fat (polyunsaturate/saturate ratio [P/S] = 2/1), would ameliorate metabolic syndrome abnormalities in women with both PCOS and metabolic syndrome. The metabolic syndrome was present in 64 (46%) of the women with PCOS. In these 64 women, there were abnormalities in waist circumference (98%), high-density lipoprotein cholesterol (HDL-C) (95%), blood pressure (70%), triglycerides (56%), and glucose (11%). In these 64 women, mean ± SD waist circumference was 116 ± 15 cm, triglyceride 192 ± 152 mg/dL, HDL-C 39 ± 7 mg/dL, systolic blood pressure 131 ± 13 mm Hg, diastolic blood pressure 83 ± 7 mm Hg, and serum glucose 94 ± 22 mg/dL. Serum insulin was high (>17 μU/mL) in 42 of the 64 women (66%). After age adjustment, 46.4% ± 4.2% of women with PCOS had the metabolic syndrome (≥3 abnormalities) versus 22.8% ± 1.1% of NHANES III women, P < .0001 versus 6% of 20 to 29-year-old and 15% of 30 to 39-year-old NHANES III women. Of the 64 women with both PCOS and the metabolic syndrome, 50 had follow-up studies after an average of 6 months on metformin and diet. At 6 months follow-up, mean percent reductions were as follows: body weight 4.7% (111 to 106 kg, P < .0001), triglycerides 14% (197 to 136 mg/dL, P = .0001), systolic blood pressure 5.2% (131 to 124 mm Hg, P = .0002), diastolic blood pressure 6% (83 to 77 mm Hg, P = .0007), and insulin 31% (25 to 17 μU/mL, P < .0001); mean percent HDL-C increased 6% (39 to 41 mg/dL, P = .013). Of these 50 women, 29 had pretreatment baseline abnormal triglycerides (≥150 mg/dL), 47 had low HDL-C (<50 mg/dL), 26 had high systolic blood pressure (≥130 mm Hg), 16 had high diastolic blood pressure (≥85 mm Hg), and 5 had glucose ≥ 110 mg/dL. On metformin plus diet at 6 months, triglycerides moved within guidelines in 10 of 29 (34%) women, HDL-C in 6 of 47 (13%), systolic blood pressure in 16 of 26 (62%), diastolic blood pressure in 10 of 16 (63%), and glucose in 3 of 5 (60%). Metformin and diet ameliorate many of the features of the metabolic syndrome, present in 46% of women with PCOS in the current study, and should reduce risk for atherothrombosis and type 2 diabetes mellitus (DM) in PCOS." @default.
• W2067094952 created "2016-06-24" @default.
• W2067094952 creator A5013736647 @default.
• W2067094952 creator A5073237424 @default.
• W2067094952 creator A5078919079 @default.
• W2067094952 creator A5079058910 @default.
• W2067094952 creator A5078067296 @default.
• W2067094952 date "2003-07-01" @default.
• W2067094952 modified "2023-10-01" @default.
• W2067094952 title "Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome" @default.
• W2067094952 cites W1966752541 @default.
• W2067094952 cites W1973870482 @default.
• W2067094952 cites W1985091774 @default.
• W2067094952 cites W1985157643 @default.
• W2067094952 cites W1986349550 @default.
• W2067094952 cites W1986432871 @default.
• W2067094952 cites W2008699478 @default.
• W2067094952 cites W2010801966 @default.
• W2067094952 cites W2017528217 @default.
• W2067094952 cites W2023807105 @default.
• W2067094952 cites W2032048326 @default.
• W2067094952 cites W2036504695 @default.
• W2067094952 cites W2044970382 @default.
• W2067094952 cites W2049702067 @default.
• W2067094952 cites W2060249166 @default.
• W2067094952 cites W2060409824 @default.
• W2067094952 cites W2060449981 @default.
• W2067094952 cites W2062244462 @default.
• W2067094952 cites W2072474124 @default.
• W2067094952 cites W2075353814 @default.
• W2067094952 cites W2078807483 @default.
• W2067094952 cites W2086515956 @default.
• W2067094952 cites W2086796651 @default.
• W2067094952 cites W2097171957 @default.
• W2067094952 cites W2102906564 @default.
• W2067094952 cites W2104483281 @default.
• W2067094952 cites W2111193328 @default.
• W2067094952 cites W2112720813 @default.
• W2067094952 cites W2126832422 @default.
• W2067094952 cites W2132594773 @default.
• W2067094952 cites W2140122568 @default.
• W2067094952 cites W2141428775 @default.
• W2067094952 cites W2146536851 @default.
• W2067094952 cites W2149183746 @default.
• W2067094952 cites W2158822657 @default.
• W2067094952 cites W2162453805 @default.
• W2067094952 cites W2169862949 @default.
• W2067094952 cites W2169875282 @default.
• W2067094952 cites W2174532933 @default.
• W2067094952 cites W2332951586 @default.
• W2067094952 cites W2337133379 @default.
• W2067094952 cites W4238465232 @default.
• W2067094952 cites W4238628454 @default.
• W2067094952 cites W4244659853 @default.
• W2067094952 cites W4254005293 @default.
• W2067094952 doi "https://doi.org/10.1016/s0026-0495(03)00104-5" @default.
• W2067094952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12870169" @default.
• W2067094952 hasPublicationYear "2003" @default.
• W2067094952 type Work @default.
• W2067094952 sameAs 2067094952 @default.
• W2067094952 citedByCount "367" @default.
• W2067094952 countsByYear W20670949522012 @default.
• W2067094952 countsByYear W20670949522013 @default.
• W2067094952 countsByYear W20670949522014 @default.
• W2067094952 countsByYear W20670949522015 @default.
• W2067094952 countsByYear W20670949522016 @default.
• W2067094952 countsByYear W20670949522017 @default.
• W2067094952 countsByYear W20670949522018 @default.
• W2067094952 countsByYear W20670949522019 @default.
• W2067094952 countsByYear W20670949522020 @default.
• W2067094952 countsByYear W20670949522021 @default.
• W2067094952 countsByYear W20670949522022 @default.
• W2067094952 countsByYear W20670949522023 @default.
• W2067094952 crossrefType "journal-article" @default.
• W2067094952 hasAuthorship W2067094952A5013736647 @default.
• W2067094952 hasAuthorship W2067094952A5073237424 @default.
• W2067094952 hasAuthorship W2067094952A5078067296 @default.
• W2067094952 hasAuthorship W2067094952A5078919079 @default.
• W2067094952 hasAuthorship W2067094952A5079058910 @default.
• W2067094952 hasConcept C120665830 @default.
• W2067094952 hasConcept C121332964 @default.
• W2067094952 hasConcept C126322002 @default.
• W2067094952 hasConcept C134018914 @default.
• W2067094952 hasConcept C2776193436 @default.
• W2067094952 hasConcept C2777391703 @default.
• W2067094952 hasConcept C2779306644 @default.
• W2067094952 hasConcept C2779874844 @default.
• W2067094952 hasConcept C2780578515 @default.
• W2067094952 hasConcept C2908647359 @default.
• W2067094952 hasConcept C3018442814 @default.
• W2067094952 hasConcept C511355011 @default.
• W2067094952 hasConcept C61511704 @default.
• W2067094952 hasConcept C71924100 @default.
• W2067094952 hasConcept C84393581 @default.
• W2067094952 hasConcept C99454951 @default.
• W2067094952 hasConceptScore W2067094952C120665830 @default.
• W2067094952 hasConceptScore W2067094952C121332964 @default.
• W2067094952 hasConceptScore W2067094952C126322002 @default.

• next