FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067096238> ?p ?o ?g. }

• W2067096238 endingPage "504" @default.
• W2067096238 startingPage "495" @default.
• W2067096238 abstract "Cellular electrophysiology is not fully understood in the atrium of pig heart. The objective of the present study was to determine whether transient outward current (Ito), ultra-rapid delayed rectifier potassium current (IKur), and rapid and slow delayed rectifier K+ currents (IKr and IKs) were present in pig atrium. The whole-cell patch technique was applied to record membrane currents and action potentials in myocytes isolated from pig atrium. It was found that an Ito was activated upon depolarization voltage steps to between –10 and +60 mV from –50 mV in pig atrial cells, and the Ito was sensitive to the inhibition by the blockade of L-type calcium (Ca2+) current, showed a “bell-shaped” I–V relationship, typical of Ito2 (i.e. ICl.Ca). The Ito2 was inhibited by the chloride (Cl–) channel blocker anthracene-9-carboxylic acid (9-AC, 200 μmol/l) or 4,4′-diisothiocyanostilben-2,2′disulfonic acid (200 μmol/l), and by Cl– substitution in the superfusate. IKur was found in pig atrial myocytes, and the current showed properties of weak inward rectification and use- and frequency-dependent reduction. IKur was resistant to tetraethylammonium, but sensitive to inhibition by 4-aminopyridine (4-AP) (IC50 = 71.7 ± 3.5 μmol/l). In addition, E-4031-sensitive IKr and chromanol 293B-sensitive IKs were observed in pig atrial myocytes. Blockade of Ito2, IKur, IKr or IKs with corresponding blockers significantly prolonged atrial action potentials. These results indicate that Ca2+-activated Ito2, 4-AP-sensitive IKur, E-4031-sensitive IKr, and 293B-sensitive IKs are present in pig atrial myocytes, and these currents play important roles in action potential repolarization of pig atria." @default.
• W2067096238 created "2016-06-24" @default.
• W2067096238 creator A5031478376 @default.
• W2067096238 creator A5038402015 @default.
• W2067096238 creator A5065770366 @default.
• W2067096238 creator A5076765345 @default.
• W2067096238 creator A5078239723 @default.
• W2067096238 date "2004-04-01" @default.
• W2067096238 modified "2023-09-30" @default.
• W2067096238 title "Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes" @default.
• W2067096238 cites W1975869151 @default.
• W2067096238 cites W1981332385 @default.
• W2067096238 cites W1993252521 @default.
• W2067096238 cites W1994064741 @default.
• W2067096238 cites W1999330457 @default.
• W2067096238 cites W1999827058 @default.
• W2067096238 cites W2005342366 @default.
• W2067096238 cites W2033045833 @default.
• W2067096238 cites W2033591053 @default.
• W2067096238 cites W2045347606 @default.
• W2067096238 cites W2047631697 @default.
• W2067096238 cites W2052582897 @default.
• W2067096238 cites W2053398592 @default.
• W2067096238 cites W2058626030 @default.
• W2067096238 cites W2062348109 @default.
• W2067096238 cites W2068175148 @default.
• W2067096238 cites W2071293796 @default.
• W2067096238 cites W2074501443 @default.
• W2067096238 cites W2078761712 @default.
• W2067096238 cites W2096056146 @default.
• W2067096238 cites W2100011512 @default.
• W2067096238 cites W2110869436 @default.
• W2067096238 cites W2115832656 @default.
• W2067096238 cites W2122508506 @default.
• W2067096238 cites W2126942951 @default.
• W2067096238 cites W2135225379 @default.
• W2067096238 cites W2137067311 @default.
• W2067096238 cites W2137266207 @default.
• W2067096238 cites W2140765579 @default.
• W2067096238 cites W2143511208 @default.
• W2067096238 cites W2148605426 @default.
• W2067096238 cites W2148867723 @default.
• W2067096238 cites W2151638020 @default.
• W2067096238 cites W2158824271 @default.
• W2067096238 cites W2159167870 @default.
• W2067096238 cites W2165880289 @default.
• W2067096238 cites W2167744805 @default.
• W2067096238 cites W2208482215 @default.
• W2067096238 cites W2236095652 @default.
• W2067096238 cites W2241090036 @default.
• W2067096238 cites W2323663120 @default.
• W2067096238 cites W2400979833 @default.
• W2067096238 cites W2409473863 @default.
• W2067096238 cites W2410044183 @default.
• W2067096238 doi "https://doi.org/10.1016/j.yjmcc.2004.01.005" @default.
• W2067096238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15081309" @default.
• W2067096238 hasPublicationYear "2004" @default.
• W2067096238 type Work @default.
• W2067096238 sameAs 2067096238 @default.
• W2067096238 citedByCount "28" @default.
• W2067096238 countsByYear W20670962382013 @default.
• W2067096238 countsByYear W20670962382014 @default.
• W2067096238 countsByYear W20670962382015 @default.
• W2067096238 countsByYear W20670962382016 @default.
• W2067096238 countsByYear W20670962382018 @default.
• W2067096238 countsByYear W20670962382019 @default.
• W2067096238 countsByYear W20670962382021 @default.
• W2067096238 countsByYear W20670962382022 @default.
• W2067096238 crossrefType "journal-article" @default.
• W2067096238 hasAuthorship W2067096238A5031478376 @default.
• W2067096238 hasAuthorship W2067096238A5038402015 @default.
• W2067096238 hasAuthorship W2067096238A5065770366 @default.
• W2067096238 hasAuthorship W2067096238A5076765345 @default.
• W2067096238 hasAuthorship W2067096238A5078239723 @default.
• W2067096238 hasConcept C101404756 @default.
• W2067096238 hasConcept C114021368 @default.
• W2067096238 hasConcept C12554922 @default.
• W2067096238 hasConcept C126322002 @default.
• W2067096238 hasConcept C147944092 @default.
• W2067096238 hasConcept C153461711 @default.
• W2067096238 hasConcept C170493617 @default.
• W2067096238 hasConcept C178790620 @default.
• W2067096238 hasConcept C181911157 @default.
• W2067096238 hasConcept C185592680 @default.
• W2067096238 hasConcept C207200792 @default.
• W2067096238 hasConcept C2778457506 @default.
• W2067096238 hasConcept C2779161974 @default.
• W2067096238 hasConcept C2780918503 @default.
• W2067096238 hasConcept C2780922449 @default.
• W2067096238 hasConcept C4141045 @default.
• W2067096238 hasConcept C50254741 @default.
• W2067096238 hasConcept C517785266 @default.
• W2067096238 hasConcept C519063684 @default.
• W2067096238 hasConcept C55493867 @default.
• W2067096238 hasConcept C71924100 @default.
• W2067096238 hasConcept C83743174 @default.
• W2067096238 hasConcept C86803240 @default.
• W2067096238 hasConcept C94924445 @default.

• next