FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067104892> ?p ?o ?g. }

• W2067104892 endingPage "181" @default.
• W2067104892 startingPage "175" @default.
• W2067104892 abstract "Prolonged dietary restriction has been reported to suppress age-induced phenomena. In order to investigate how prolonged caloric restriction reduces age-related deterioration of hippocampal synaptic transmission, we compared the levels of major hippocampal polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid between 4- and 26-month-old rats. The Ca2+ responses upon perfusion of NMDA or 30 mM K+ between 4- and 26-month-old rats with prolonged dietary restriction were also compared using the fluorescent probe Fura-2. A decrease in membrane arachidonic acid is thought to be a major causal factor in the age-related impairment of long-term potentiation. Long-term caloric restriction seems to increase arachidonic acid levels regardless of age. However, there is no significant difference of hippocampal arachidonic acid levels between in freely feeding 4- and 26-month-old rats. Similar results were obtained from the measurement of hippocampal docosahexaenoic acid levels. Under caloric restriction, the 500 μM N-methyl-d-aspartate-induced Ca2+ response was greatly reduced by aging, while the 30 mM K+-induced Ca2+ response was not affected. In our preliminary data, the amplitude of the population spike after tetanic stimulation did not differ between 4- and 26-month-old rats under caloric restriction, while 50 μM of 2-amino-5-phosphonovaleric acid, a N-methyl-d-aspartate antagonist, markedly inhibited a potentiation of the population spike in 4-month-old rats, but with negligible inhibition in 26-month-old rats. From these results, an age-related impairment of hippocampal excitatory synaptic transmission may not be solely due to the reduction of membrane arachidonic acid. Caloric restriction might prevent age-related reduction in hippocampal synaptic transmission by enhancing non-N-methyl-d-aspartate mechanisms." @default.
• W2067104892 created "2016-06-24" @default.
• W2067104892 creator A5002048322 @default.
• W2067104892 creator A5007146138 @default.
• W2067104892 creator A5035860681 @default.
• W2067104892 creator A5057546755 @default.
• W2067104892 creator A5060319150 @default.
• W2067104892 creator A5071691947 @default.
• W2067104892 creator A5089369776 @default.
• W2067104892 date "2003-03-01" @default.
• W2067104892 modified "2023-10-18" @default.
• W2067104892 title "How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?" @default.
• W2067104892 cites W1518939040 @default.
• W2067104892 cites W1519245788 @default.
• W2067104892 cites W1601176830 @default.
• W2067104892 cites W1946992976 @default.
• W2067104892 cites W1951842502 @default.
• W2067104892 cites W1967626297 @default.
• W2067104892 cites W1970187644 @default.
• W2067104892 cites W1982647833 @default.
• W2067104892 cites W1984251709 @default.
• W2067104892 cites W1992594183 @default.
• W2067104892 cites W1993307171 @default.
• W2067104892 cites W1995296422 @default.
• W2067104892 cites W1997228449 @default.
• W2067104892 cites W1998041120 @default.
• W2067104892 cites W2001854860 @default.
• W2067104892 cites W2009989842 @default.
• W2067104892 cites W2012071630 @default.
• W2067104892 cites W2018297253 @default.
• W2067104892 cites W2052884971 @default.
• W2067104892 cites W2056514603 @default.
• W2067104892 cites W2064575305 @default.
• W2067104892 cites W2073805066 @default.
• W2067104892 cites W2076183513 @default.
• W2067104892 cites W2076405234 @default.
• W2067104892 cites W2080700455 @default.
• W2067104892 cites W2084201655 @default.
• W2067104892 cites W2084960677 @default.
• W2067104892 cites W2096397785 @default.
• W2067104892 cites W2108363649 @default.
• W2067104892 cites W2110724392 @default.
• W2067104892 cites W2119883995 @default.
• W2067104892 cites W2120535747 @default.
• W2067104892 cites W2120905810 @default.
• W2067104892 cites W2126403835 @default.
• W2067104892 cites W2127760670 @default.
• W2067104892 cites W2129542892 @default.
• W2067104892 cites W2151425581 @default.
• W2067104892 cites W2152311269 @default.
• W2067104892 cites W2153210359 @default.
• W2067104892 cites W2168849139 @default.
• W2067104892 cites W2341161626 @default.
• W2067104892 cites W43853842 @default.
• W2067104892 doi "https://doi.org/10.1016/s0169-328x(03)00028-7" @default.
• W2067104892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12654517" @default.
• W2067104892 hasPublicationYear "2003" @default.
• W2067104892 type Work @default.
• W2067104892 sameAs 2067104892 @default.
• W2067104892 citedByCount "23" @default.
• W2067104892 countsByYear W20671048922014 @default.
• W2067104892 countsByYear W20671048922016 @default.
• W2067104892 countsByYear W20671048922018 @default.
• W2067104892 countsByYear W20671048922019 @default.
• W2067104892 countsByYear W20671048922020 @default.
• W2067104892 countsByYear W20671048922021 @default.
• W2067104892 crossrefType "journal-article" @default.
• W2067104892 hasAuthorship W2067104892A5002048322 @default.
• W2067104892 hasAuthorship W2067104892A5007146138 @default.
• W2067104892 hasAuthorship W2067104892A5035860681 @default.
• W2067104892 hasAuthorship W2067104892A5057546755 @default.
• W2067104892 hasAuthorship W2067104892A5060319150 @default.
• W2067104892 hasAuthorship W2067104892A5071691947 @default.
• W2067104892 hasAuthorship W2067104892A5089369776 @default.
• W2067104892 hasConcept C112592302 @default.
• W2067104892 hasConcept C126322002 @default.
• W2067104892 hasConcept C134018914 @default.
• W2067104892 hasConcept C148762608 @default.
• W2067104892 hasConcept C170493617 @default.
• W2067104892 hasConcept C17077164 @default.
• W2067104892 hasConcept C181199279 @default.
• W2067104892 hasConcept C19038510 @default.
• W2067104892 hasConcept C200170125 @default.
• W2067104892 hasConcept C25274449 @default.
• W2067104892 hasConcept C2776464000 @default.
• W2067104892 hasConcept C2777171753 @default.
• W2067104892 hasConcept C2778078955 @default.
• W2067104892 hasConcept C2779277159 @default.
• W2067104892 hasConcept C2781161787 @default.
• W2067104892 hasConcept C2908647359 @default.
• W2067104892 hasConcept C543025807 @default.
• W2067104892 hasConcept C55493867 @default.
• W2067104892 hasConcept C67018056 @default.
• W2067104892 hasConcept C6742658 @default.
• W2067104892 hasConcept C71924100 @default.
• W2067104892 hasConcept C86803240 @default.
• W2067104892 hasConcept C99454951 @default.
• W2067104892 hasConceptScore W2067104892C112592302 @default.

• next