Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067108500> ?p ?o ?g. }
- W2067108500 endingPage "206" @default.
- W2067108500 startingPage "197" @default.
- W2067108500 abstract "Abstract Microglia, the major immune effector cells in the central nervous system, are activated when the brain suffers injury. A number of studies indicate that gangliosides activate microglia. However, the signaling mechanisms involved in microglial activation are not yet to be elucidated. Our results show that gangliosides induce the expression of interleukin (IL)‐1β, tumor necrosis factor‐α (TNF‐α), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase. Expression of IL‐1β, TNF‐α, and iNOS in ganglioside‐treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Gö6976, Ro31‐8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). In response to gangliosides, PKC‐α, βII, and δ and NADPH oxidase p67 phox translocated from the cytosol to the membrane. ROS generation was also activated within 5 min of ganglioside treatment. Ganglioside‐induced ROS generation was blocked by PKC inhibitors. Furthermore, ganglioside‐induced activation of NF‐κB, an essential transcription factor that mediates the expression of IL‐1β, TNF‐α, and iNOS, was reduced in the presence of GF109203X and DPI. Our results collectively suggest that gangliosides activate microglia via PKC and NADPH oxidase, which regulate activation of NF‐κB. © 2004 Wiley‐Liss, Inc." @default.
- W2067108500 created "2016-06-24" @default.
- W2067108500 creator A5040492220 @default.
- W2067108500 creator A5052021476 @default.
- W2067108500 creator A5057974303 @default.
- W2067108500 creator A5060511427 @default.
- W2067108500 creator A5060680796 @default.
- W2067108500 creator A5070789043 @default.
- W2067108500 date "2004-06-15" @default.
- W2067108500 modified "2023-10-18" @default.
- W2067108500 title "Gangliosides activate microglia via protein kinase C and NADPH oxidase" @default.
- W2067108500 cites W1494669487 @default.
- W2067108500 cites W1540820582 @default.
- W2067108500 cites W1568529372 @default.
- W2067108500 cites W1582795450 @default.
- W2067108500 cites W161395021 @default.
- W2067108500 cites W1641731911 @default.
- W2067108500 cites W1667711738 @default.
- W2067108500 cites W1670607653 @default.
- W2067108500 cites W1784761870 @default.
- W2067108500 cites W1786911182 @default.
- W2067108500 cites W1822066871 @default.
- W2067108500 cites W1904705252 @default.
- W2067108500 cites W1942225097 @default.
- W2067108500 cites W1964980219 @default.
- W2067108500 cites W1966613691 @default.
- W2067108500 cites W1972149030 @default.
- W2067108500 cites W1972926770 @default.
- W2067108500 cites W1972936661 @default.
- W2067108500 cites W1980045097 @default.
- W2067108500 cites W1988261409 @default.
- W2067108500 cites W1998592507 @default.
- W2067108500 cites W1998798350 @default.
- W2067108500 cites W1999190313 @default.
- W2067108500 cites W2004681520 @default.
- W2067108500 cites W2011361113 @default.
- W2067108500 cites W2012604352 @default.
- W2067108500 cites W2013052548 @default.
- W2067108500 cites W2013237027 @default.
- W2067108500 cites W2015572452 @default.
- W2067108500 cites W2016146035 @default.
- W2067108500 cites W2016280107 @default.
- W2067108500 cites W2016348467 @default.
- W2067108500 cites W2025461456 @default.
- W2067108500 cites W2027149317 @default.
- W2067108500 cites W2028134786 @default.
- W2067108500 cites W2029918145 @default.
- W2067108500 cites W2031141849 @default.
- W2067108500 cites W2031643961 @default.
- W2067108500 cites W2034603447 @default.
- W2067108500 cites W2040419928 @default.
- W2067108500 cites W2045764828 @default.
- W2067108500 cites W2064645610 @default.
- W2067108500 cites W2064859977 @default.
- W2067108500 cites W2068502127 @default.
- W2067108500 cites W2069717499 @default.
- W2067108500 cites W2071247864 @default.
- W2067108500 cites W2071881710 @default.
- W2067108500 cites W2074885818 @default.
- W2067108500 cites W2078056296 @default.
- W2067108500 cites W2079183404 @default.
- W2067108500 cites W2082807944 @default.
- W2067108500 cites W2083636462 @default.
- W2067108500 cites W2084699108 @default.
- W2067108500 cites W2093041047 @default.
- W2067108500 cites W2093881154 @default.
- W2067108500 cites W2106760961 @default.
- W2067108500 cites W2114648315 @default.
- W2067108500 cites W2119456253 @default.
- W2067108500 cites W2133132655 @default.
- W2067108500 cites W2134498505 @default.
- W2067108500 cites W2146901670 @default.
- W2067108500 cites W2159157105 @default.
- W2067108500 cites W2352036364 @default.
- W2067108500 cites W235855033 @default.
- W2067108500 cites W311005666 @default.
- W2067108500 cites W82814575 @default.
- W2067108500 doi "https://doi.org/10.1002/glia.20069" @default.
- W2067108500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15390122" @default.
- W2067108500 hasPublicationYear "2004" @default.
- W2067108500 type Work @default.
- W2067108500 sameAs 2067108500 @default.
- W2067108500 citedByCount "96" @default.
- W2067108500 countsByYear W20671085002012 @default.
- W2067108500 countsByYear W20671085002013 @default.
- W2067108500 countsByYear W20671085002014 @default.
- W2067108500 countsByYear W20671085002015 @default.
- W2067108500 countsByYear W20671085002016 @default.
- W2067108500 countsByYear W20671085002017 @default.
- W2067108500 countsByYear W20671085002018 @default.
- W2067108500 countsByYear W20671085002019 @default.
- W2067108500 countsByYear W20671085002020 @default.
- W2067108500 countsByYear W20671085002021 @default.
- W2067108500 countsByYear W20671085002022 @default.
- W2067108500 countsByYear W20671085002023 @default.
- W2067108500 crossrefType "journal-article" @default.
- W2067108500 hasAuthorship W2067108500A5040492220 @default.
- W2067108500 hasAuthorship W2067108500A5052021476 @default.