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- W2067111947 abstract "The interesting pharmacological properties of neoboutomellerones 1 and 2 were the basis for the assembly of a small library of analogues consisting of natural products isolated from the plant Neoboutonia melleri and of semisynthetic derivatives. As the two enone systems (C23-C24a and C1-C3) and the two hydroxyls groups (C22 and C26) of neoboutomellerones are required for activity, modifications were focused on these functional groups. Biological evaluation by using a cellular assay for proteasome activity provided clues regarding the mechanism of action of these natural products and synthetic derivatives. Certain neoboutomellerone derivatives inhibited the proliferation of human WM-266-4 melanoma tumor cells at submicromolar concentration and warrant evaluation as anticancer agents." @default.
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- W2067111947 date "2012-01-01" @default.
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- W2067111947 title "Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors" @default.
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- W2067111947 doi "https://doi.org/10.1016/j.bmc.2011.11.066" @default.
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