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• W2067125561 startingPage "1427" @default.
• W2067125561 abstract "To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1-100 microg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive Vbeta8+ cells at the level of the semi-mature population of HSAhi CD4+ 8- cells found in the thymic medulla; deletion of CD4+ 8+ cells was minimal. SEB injection also caused marked elimination of Vbeta8+ HSAhi CD4+ 8- thymocytes in lpr/lpr mice. Paradoxically, however, elimination of these cells in lpr/lpr mice was induced by low-to-moderate doses of SEB (</=1 microg) but not by high doses (100 microg). Similar findings applied when T cell receptor transgenic mice were injected with specific peptide. These findings suggest that clonal elimination of semi-mature medullary T cells is Fas independent at low doses of antigen but Fas dependent at high doses. Previous reports documenting that negative selection is not obviously impaired in lpr/lpr mice could thus reflect that the antigens studied were expressed at only a low level." @default.
• W2067125561 created "2016-06-24" @default.
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• W2067125561 date "1998-05-04" @default.
• W2067125561 modified "2023-10-16" @default.
• W2067125561 title "A Role for Fas in Negative Selection of Thymocytes In Vivo" @default.
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• W2067125561 doi "https://doi.org/10.1084/jem.187.9.1427" @default.
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• W2067125561 hasPublicationYear "1998" @default.
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