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- W2067133090 abstract "The role of cholinergic basal forebrain projections in the modulation of cortical plasticity and associated functional changes is currently the subject of renewed attention. Excitatory amino acid receptors have been identified as mediators of cortical topographic efferent and afferent information. In addition some of these receptors, notably the NMDA and metabotropic [mGluR] type, participate in cortical plasticity. Growing evidence suggests that interactions between cholinergic and glutamatergic systems contribute to cognitive cortical functions and their anatomical and physiological substrates. Though cholinergic and glutamatergic mechanisms have both been shown to be involved in cortical morphogenesis, few studies have attempted to study their interactions in development. The present study investigates the effect of neonatal lesions to the cholinergic basal forebrain on NMDA, AMPA and mGluR receptors in BALB/CByJ mice, at two different developmental ages. We demonstrated previously that nBM lesions at birth result in transient cholinergic depletion for the first two postnatal weeks, substantial morphogenetic alterations in neocortex and cognitive deficits by adulthood. We show here that unilateral neonatal lesions result in decreases in NMDA and AMPA receptors but increases in mGluRs during the second postnatal week (PND 14). At 30 days postnatal, lesion mediated changes were attenuated, compared with PND 14, but significant sex differences in control and nBM lesioned mice were apparent. These data support the notion that cholinergic/glutamatergic interactions are important during early cortical morphogenesis. Moreover, our results highlight the fact that cholinergic as well glutamatergic developmental mechanisms are sexually dimorphic." @default.
- W2067133090 created "2016-06-24" @default.
- W2067133090 creator A5028424382 @default.
- W2067133090 creator A5036549379 @default.
- W2067133090 creator A5048940403 @default.
- W2067133090 creator A5087413391 @default.
- W2067133090 date "1998-11-01" @default.
- W2067133090 modified "2023-09-27" @default.
- W2067133090 title "Effects of neonatal cholinergic basal forebrainlesions on excitatory amino acid receptors in neocortex" @default.
- W2067133090 cites W140113638 @default.
- W2067133090 cites W1488634403 @default.
- W2067133090 cites W1532243186 @default.
- W2067133090 cites W1542087562 @default.
- W2067133090 cites W1561541164 @default.
- W2067133090 cites W1571948966 @default.
- W2067133090 cites W1578028098 @default.
- W2067133090 cites W1599639323 @default.
- W2067133090 cites W1601167079 @default.
- W2067133090 cites W1679865271 @default.
- W2067133090 cites W1963747370 @default.
- W2067133090 cites W1966629521 @default.
- W2067133090 cites W1968001076 @default.
- W2067133090 cites W1973023260 @default.
- W2067133090 cites W1973334224 @default.
- W2067133090 cites W1974718962 @default.
- W2067133090 cites W1978222372 @default.
- W2067133090 cites W1979860148 @default.
- W2067133090 cites W1979887029 @default.
- W2067133090 cites W1980805844 @default.
- W2067133090 cites W1983340457 @default.
- W2067133090 cites W1986652867 @default.
- W2067133090 cites W1989670552 @default.
- W2067133090 cites W1989685432 @default.
- W2067133090 cites W1990370575 @default.
- W2067133090 cites W1991334913 @default.
- W2067133090 cites W1993445772 @default.
- W2067133090 cites W1996741916 @default.
- W2067133090 cites W1996930549 @default.
- W2067133090 cites W2002171173 @default.
- W2067133090 cites W2002665203 @default.
- W2067133090 cites W2005595008 @default.
- W2067133090 cites W2006332735 @default.
- W2067133090 cites W2007580998 @default.
- W2067133090 cites W2009279607 @default.
- W2067133090 cites W2009354161 @default.
- W2067133090 cites W2010101907 @default.
- W2067133090 cites W2010461048 @default.
- W2067133090 cites W2011055552 @default.
- W2067133090 cites W2011448874 @default.
- W2067133090 cites W2017213222 @default.
- W2067133090 cites W2019374608 @default.
- W2067133090 cites W2021779512 @default.
- W2067133090 cites W2024945446 @default.
- W2067133090 cites W2025506523 @default.
- W2067133090 cites W2025801062 @default.
- W2067133090 cites W2028837606 @default.
- W2067133090 cites W2030553912 @default.
- W2067133090 cites W2031917138 @default.
- W2067133090 cites W2032202532 @default.
- W2067133090 cites W2034408566 @default.
- W2067133090 cites W2036117787 @default.
- W2067133090 cites W2037076830 @default.
- W2067133090 cites W2039684695 @default.
- W2067133090 cites W2040352008 @default.
- W2067133090 cites W2040506116 @default.
- W2067133090 cites W2040557425 @default.
- W2067133090 cites W2042266665 @default.
- W2067133090 cites W2043166209 @default.
- W2067133090 cites W2043457433 @default.
- W2067133090 cites W2050968741 @default.
- W2067133090 cites W2057196184 @default.
- W2067133090 cites W2057884808 @default.
- W2067133090 cites W2066098527 @default.
- W2067133090 cites W2068055544 @default.
- W2067133090 cites W2068898997 @default.
- W2067133090 cites W2070933799 @default.
- W2067133090 cites W2074855098 @default.
- W2067133090 cites W2076765847 @default.
- W2067133090 cites W2078455670 @default.
- W2067133090 cites W2080551656 @default.
- W2067133090 cites W2088478128 @default.
- W2067133090 cites W2088792316 @default.
- W2067133090 cites W2092254724 @default.
- W2067133090 cites W2093545276 @default.
- W2067133090 cites W2096120932 @default.
- W2067133090 cites W2111516838 @default.
- W2067133090 cites W2113630547 @default.
- W2067133090 cites W2122972371 @default.
- W2067133090 cites W2132610064 @default.
- W2067133090 cites W2133052659 @default.
- W2067133090 cites W2134646026 @default.
- W2067133090 cites W2135068208 @default.
- W2067133090 cites W2135554966 @default.
- W2067133090 cites W2138335036 @default.
- W2067133090 cites W2145107163 @default.
- W2067133090 cites W2160210296 @default.
- W2067133090 cites W2161612105 @default.
- W2067133090 cites W2172403866 @default.