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• W2067139831 startingPage "84" @default.
• W2067139831 abstract "Beetles, like other insects, depend on diuretic and antidiuretic hormones to control water balance. We have isolated, using head extracts from the beetle Tenebrio molitor , a peptide that strongly inhibits fluid secretion by the Malpighian tubules of this insect. This antidiuretic factor (ADF) appears to elicit its effect via cGMP as a second messenger but does not stimulate NO production. It has primary structure: Val-Val-Asn-Thr-Pro-Gly-His-Ala-Val-Ser-Tyr-His-Val-Tyr-OH. The ADF inhibits tubule secretion with high potency: the EC 50 is around 10 fM. It bears no significant resemblance to other biologically active neuropeptides. To our knowledge this is the only endogenous insect ADF acting on Malpighian tubules to be sequenced, and the first coleopteran (beetle) antidiuretic factor fully characterized to date." @default.
• W2067139831 created "2016-06-24" @default.
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• W2067139831 date "2001-12-26" @default.
• W2067139831 modified "2023-10-17" @default.
• W2067139831 title "Identification of a potent antidiuretic factor acting on beetle Malpighian tubules" @default.
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• W2067139831 doi "https://doi.org/10.1073/pnas.012436199" @default.
• W2067139831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/117518" @default.
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