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- W2067152046 abstract "Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in the development of tolerance. In our experimental conditions, no obvious toxicity was observed. These results may suggest for polyamines a role in nociception, and may disclose a new class of analgesic drugs." @default.
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- W2067152046 date "1984-06-01" @default.
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- W2067152046 title "Putrescine has analgesic activity, in rats" @default.
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- W2067152046 doi "https://doi.org/10.1016/0024-3205(84)90429-6" @default.
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