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- W2067153003 abstract "Exogenous prostaglandins (PGs) have been shown to have differing effects on frog lung contractility. In this study, prostaglandin synthesis was measured in lung tissues from warm-acclimated (WA, 22°C) and cold-acclimated (CA, 5°C) American bullfrogs, Rana catesbeiana, incubated for 30 min at 5° or 22°C. Media were assayed by radioimmunoassay for PGE2, PGF2α, 6-keto PGF1α (the metabolite of PGI2), and thromboxane (TX)B2 (the metabolite of TXA2). PGE2 was produced in greatest quantity by tissues from WA and CA animals, at both incubation temperatures. Epinephrine stimulated PGE2, PGF2α, and TXB2 synthesis at 22°C but only stimulated PGE2 production at 5°C. In tissues from CA frogs, epinephrine did not stimulate prostaglandin synthesis at either incubation temperature. Ibuprofen (10−5 M) inhibited basal and epinephrine-stimulated prostaglandin synthesis in tissues from WA frogs incubated at 22°C. The beta receptor antagonist propranolol (10−6M) blocked the epinephrine-stimulated synthesis of PGE2, PGF2α and TXB2, suggesting epinephrine stimulates prostaglandin synthesis through beta receptor activation. The absence of stimulation by epinephrine in lung from CA animals, but not in 5°C incubations of tissues from WA animals, suggests that a modification of beta receptors occurs during prolonged cold exposure." @default.
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- W2067153003 date "1988-10-01" @default.
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- W2067153003 title "Epinephrine stimulates prostaglandin synthesis by bullfrog lung from warm-acclimated, but not cold-acclimated, animals" @default.
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- W2067153003 doi "https://doi.org/10.1002/jez.1402480113" @default.
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