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- W2067185757 abstract "Recent population data suggest independence of the genetic polymorphisms in mephenytoin and sparteine I debrisoquine oxidation. We used human liver preparations to test whether mephenytoin competes with sparteine for binding to the genetically variable cytochrome P-450, which mediates metabolism of both sparteine and debrisoquine. Mephenytoin failed to inhibit in vitro sparteine oxidation. This provides biochemical evidence that the polymorphism of sparteine/debrisoquine metabolism is not related to that of mephenytoin. Clinical Pharmacology and Therapeutics (1984) 35, 426–428; doi:10.1038/clpt.1984.54" @default.
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- W2067185757 date "1984-03-01" @default.
- W2067185757 modified "2023-09-24" @default.
- W2067185757 title "Sparteine oxidation by the human liver: Absence of inhibition by mephenytoin" @default.
- W2067185757 doi "https://doi.org/10.1038/clpt.1984.54" @default.
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