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• W2067192846 abstract "Endothelial receptor tyrosine kinases may play important roles in pathological vascular growth, particularly in tumours. In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in breast tumours (n = 123). Tie2 expression was detected in the endothelium of all breast tissues examined. However, the strongest expression of Tie-2 was seen in vascular 'hot spots' within the inflammatory infiltrate at the periphery of invasive tumours. Moreover, the proportion of Tie2-positive vessels (Tie2 counts/CD31 counts) was significantly higher in breast tumours than the proportion of Tie2-positive vessels in either normal breast tissue or benign breast lesions (P = 0.004 and 0.0001 respectively). These data are consistent with a role for Tie2 in tumour angiogenesis and demonstrate the potential use of Tie2 expression as a novel marker of the tumour vasculature." @default.
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• W2067192846 date "1998-01-01" @default.
• W2067192846 modified "2023-10-07" @default.
• W2067192846 title "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis" @default.
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• W2067192846 doi "https://doi.org/10.1038/bjc.1998.8" @default.
• W2067192846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2151265" @default.
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• W2067192846 hasPublicationYear "1998" @default.
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