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- W2067203940 abstract "Liver is a major target of nanoparticles accumulation. Here we have analyzed the liver function and activation of liver macrophages, which are sensitive to alteration of liver internal environment after repeated exposure to aluminum oxide nanoparticles. Sprague-Dawley rats where intraperitoneally injected very two days for 60 dyas with aluminum oxide nanoparticles (50mg/kg), non-nanoaluminum oxide (50mg/kg) and saline. After 60 days exposure, the concentrations of alanine aminotransferase and aspartic transaminase in plasma were significantly higher in nanoaluminum oxide group than non-nanoaluminum oxide and control groups. The number of ED-1 + and GFAP + cells in liver of nanoaluminum oxide and non-nanoaluminum oxide groups increased significantly than control group. Compared with non-nanoaluminum oxide, aluminum oxide nanoparticles display potential adverse effects on the hypatocytes and biliary tract of rat liver and less stimulus to macrophages in liver than non-nanoaluminum oxide. It is suggested that part aluminum oxide nanoparticles avoided from phagocytosis by liver macrophages. The effects of aluminum oxide nanoparticles exposure should be assessed for its potential hepatic toxicology." @default.
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- W2067203940 date "2012-03-01" @default.
- W2067203940 modified "2023-10-15" @default.
- W2067203940 title "Cell Activation and Function Alteration in Rat Livers Induced by Repeated Aluminum Oxide Nanoparticles Exposure" @default.
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- W2067203940 doi "https://doi.org/10.4028/www.scientific.net/amr.486.75" @default.
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