FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067204517> ?p ?o ?g. }

• W2067204517 endingPage "288" @default.
• W2067204517 startingPage "283" @default.
• W2067204517 abstract "The present study was designed to investigate the relaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP), a new metabolite from Salvia miltiorrhiza, on rat mesenteric artery. Isolated mesenteric arterial rings were mounted in organ baths and the isometric tension changes were measured continuously by a sensitive myograph system. The results showed that IDHP at concentrations greater than 0.1 nM produced a concentration-dependent relaxation of artery contracted by norepinephrine with pEC(50) of 7.41+/-0.08. Removal of the endothelium did not affect this relaxation, suggesting that IDHP exerted a direct effect on vascular smooth muscle cells. Meanwhile, the vasorelaxant effect of IDHP was unaffected by pre-treatment with ATP-sensitive K(+) channel inhibitor glibenclamide, delayed rectifier K(+) channel inhibitor 4-aminopyridine, inwardly rectifying K(+) channel inhibitor barium chloride and beta-adrenoceptor antagonist propranolol. However, the non-specific K(+) channel inhibitor tetraethylammonium (TEA, 3 mM) produced a rightward shift of 1.8 fold on the concentration-response curve of IDHP. Moreover, IDHP shifted the concentration-response curve of CaCl(2) as well as two receptor-mediated constrictors, phenylephrine and 5-hydroxytryptamine, to the right in a non-parallel manner. In the absence of extracellular Ca(2+), IDHP depressed the contractions induced by norepinephrine and CaCl(2), and the maximal inhibitions were 48.3+/-18.9% and 58.4+/-10.9%, respectively. These results suggest that IDHP exerts a vasorelaxant effect by inhibiting both Ca(2+) release from intracellular stores and Ca(2+) influx through voltage-dependent calcium channels, and receptor-operated calcium channels in vascular smooth muscle cells. In addition, activation of vascular TEA-sensitive K(+) channels may be partially involved in the relaxant effect of IDHP." @default.
• W2067204517 created "2016-06-24" @default.
• W2067204517 creator A5000834089 @default.
• W2067204517 creator A5016270123 @default.
• W2067204517 creator A5031636414 @default.
• W2067204517 creator A5035026551 @default.
• W2067204517 creator A5057304492 @default.
• W2067204517 creator A5058135877 @default.
• W2067204517 creator A5069165624 @default.
• W2067204517 creator A5085943321 @default.
• W2067204517 date "2008-01-01" @default.
• W2067204517 modified "2023-09-23" @default.
• W2067204517 title "Vasorelaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery" @default.
• W2067204517 cites W1971633953 @default.
• W2067204517 cites W1974879533 @default.
• W2067204517 cites W1977286692 @default.
• W2067204517 cites W1978621393 @default.
• W2067204517 cites W1981235329 @default.
• W2067204517 cites W1982638203 @default.
• W2067204517 cites W2004220155 @default.
• W2067204517 cites W2007267432 @default.
• W2067204517 cites W2018578102 @default.
• W2067204517 cites W2024282534 @default.
• W2067204517 cites W2029796239 @default.
• W2067204517 cites W2033421040 @default.
• W2067204517 cites W2036988206 @default.
• W2067204517 cites W203949027 @default.
• W2067204517 cites W2055878000 @default.
• W2067204517 cites W2060989352 @default.
• W2067204517 cites W2080439283 @default.
• W2067204517 cites W2082392252 @default.
• W2067204517 cites W2086879523 @default.
• W2067204517 cites W2088278923 @default.
• W2067204517 cites W2088300016 @default.
• W2067204517 cites W2094303056 @default.
• W2067204517 cites W2106090480 @default.
• W2067204517 cites W2106952730 @default.
• W2067204517 cites W2112520390 @default.
• W2067204517 cites W2115599934 @default.
• W2067204517 cites W2119062100 @default.
• W2067204517 cites W2136466466 @default.
• W2067204517 cites W2147069120 @default.
• W2067204517 cites W2154066769 @default.
• W2067204517 cites W2159942182 @default.
• W2067204517 cites W2771404230 @default.
• W2067204517 doi "https://doi.org/10.1016/j.ejphar.2007.10.009" @default.
• W2067204517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17976578" @default.
• W2067204517 hasPublicationYear "2008" @default.
• W2067204517 type Work @default.
• W2067204517 sameAs 2067204517 @default.
• W2067204517 citedByCount "35" @default.
• W2067204517 countsByYear W20672045172012 @default.
• W2067204517 countsByYear W20672045172013 @default.
• W2067204517 countsByYear W20672045172014 @default.
• W2067204517 countsByYear W20672045172015 @default.
• W2067204517 countsByYear W20672045172018 @default.
• W2067204517 countsByYear W20672045172019 @default.
• W2067204517 countsByYear W20672045172020 @default.
• W2067204517 countsByYear W20672045172021 @default.
• W2067204517 countsByYear W20672045172022 @default.
• W2067204517 countsByYear W20672045172023 @default.
• W2067204517 crossrefType "journal-article" @default.
• W2067204517 hasAuthorship W2067204517A5000834089 @default.
• W2067204517 hasAuthorship W2067204517A5016270123 @default.
• W2067204517 hasAuthorship W2067204517A5031636414 @default.
• W2067204517 hasAuthorship W2067204517A5035026551 @default.
• W2067204517 hasAuthorship W2067204517A5057304492 @default.
• W2067204517 hasAuthorship W2067204517A5058135877 @default.
• W2067204517 hasAuthorship W2067204517A5069165624 @default.
• W2067204517 hasAuthorship W2067204517A5085943321 @default.
• W2067204517 hasConcept C120770815 @default.
• W2067204517 hasConcept C126322002 @default.
• W2067204517 hasConcept C134018914 @default.
• W2067204517 hasConcept C142724271 @default.
• W2067204517 hasConcept C153461711 @default.
• W2067204517 hasConcept C170493617 @default.
• W2067204517 hasConcept C178790620 @default.
• W2067204517 hasConcept C185592680 @default.
• W2067204517 hasConcept C188947578 @default.
• W2067204517 hasConcept C204787440 @default.
• W2067204517 hasConcept C2776332195 @default.
• W2067204517 hasConcept C2776820930 @default.
• W2067204517 hasConcept C2776885963 @default.
• W2067204517 hasConcept C2777952589 @default.
• W2067204517 hasConcept C2778122271 @default.
• W2067204517 hasConcept C2779768347 @default.
• W2067204517 hasConcept C2779941686 @default.
• W2067204517 hasConcept C2780648677 @default.
• W2067204517 hasConcept C2780771799 @default.
• W2067204517 hasConcept C2780918503 @default.
• W2067204517 hasConcept C2781295685 @default.
• W2067204517 hasConcept C517785266 @default.
• W2067204517 hasConcept C519063684 @default.
• W2067204517 hasConcept C55493867 @default.
• W2067204517 hasConcept C555293320 @default.
• W2067204517 hasConcept C71924100 @default.
• W2067204517 hasConcept C84393581 @default.
• W2067204517 hasConcept C98274493 @default.

• next