FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067214912> ?p ?o ?g. }

• W2067214912 endingPage "346" @default.
• W2067214912 startingPage "339" @default.
• W2067214912 abstract "The biological actions of retinoic acid (RA) are mediated by retinoic acid receptors (RARalpha, -beta, and -gamma) and retinoid X receptors (RXRalpha, -beta, and -gamma). Although the ligand-binding domains of RARs and RXRs have been suggested to share the same novel folding pattern, the ligand-binding pockets of each of the retinoid receptors must have unique structural features since it has been possible to develop RAR subtype-selective and RXR-selective retinoids. We have previously demonstrated the importance for RA binding and RA-dependent transactivation of Arg(276) in RARalpha and Arg(278) in RARgamma; however, in RARbeta Arg(269) functions in conjunction with Lys(220). Here we have examined the role of the hydroxyl group of RARgamma Ser(289) and its homologous amino acid residues in RARalpha (Ser(287)) and RARbeta (Ser(280)) alone and in conjunction with their respective RARgamma Arg(278) homologs for RA binding and RA-dependent transactivation activity. The hydroxyl group of this Ser in all three RARs was found by itself not to be important for RA binding and RA-dependent transactivation activity. However, in RARalpha and RARgamma this Ser appears to play a small role in conjunction with Arg(276) and Arg(278), respectively, for these activities. Alternatively, strong synergism was observed in RARbeta between Ser(280) and Arg(269) for RA-binding and RA-dependent transactivation activity. This provides further evidence that the mechanism of interaction between the carboxylate group of retinoids and the amino acid residues in the ligand binding pocket of RARbeta is different from that of RARalpha and RARgamma." @default.
• W2067214912 created "2016-06-24" @default.
• W2067214912 creator A5016361659 @default.
• W2067214912 creator A5037340003 @default.
• W2067214912 creator A5054673383 @default.
• W2067214912 creator A5059484191 @default.
• W2067214912 creator A5060555023 @default.
• W2067214912 creator A5071822877 @default.
• W2067214912 date "2000-08-01" @default.
• W2067214912 modified "2023-10-14" @default.
• W2067214912 title "Role of Ser289 in RARγ and Its Homologous Amino Acid Residue of RARα and RARβ in the Binding of Retinoic Acid" @default.
• W2067214912 cites W102030471 @default.
• W2067214912 cites W1493100105 @default.
• W2067214912 cites W1529564662 @default.
• W2067214912 cites W182627651 @default.
• W2067214912 cites W1927684145 @default.
• W2067214912 cites W1967961154 @default.
• W2067214912 cites W1973209839 @default.
• W2067214912 cites W1977713113 @default.
• W2067214912 cites W1981765089 @default.
• W2067214912 cites W1983649348 @default.
• W2067214912 cites W1984509210 @default.
• W2067214912 cites W2005950263 @default.
• W2067214912 cites W2008494281 @default.
• W2067214912 cites W2014281019 @default.
• W2067214912 cites W2016715827 @default.
• W2067214912 cites W2022708373 @default.
• W2067214912 cites W2030488757 @default.
• W2067214912 cites W2040053707 @default.
• W2067214912 cites W2041270901 @default.
• W2067214912 cites W2042901562 @default.
• W2067214912 cites W2049791242 @default.
• W2067214912 cites W2054468433 @default.
• W2067214912 cites W2055972840 @default.
• W2067214912 cites W2060687144 @default.
• W2067214912 cites W2061178138 @default.
• W2067214912 cites W2072137070 @default.
• W2067214912 cites W2072233737 @default.
• W2067214912 cites W2082317076 @default.
• W2067214912 cites W2084050371 @default.
• W2067214912 cites W2119806021 @default.
• W2067214912 cites W2141662437 @default.
• W2067214912 cites W2151626885 @default.
• W2067214912 cites W2217888991 @default.
• W2067214912 cites W2949429975 @default.
• W2067214912 doi "https://doi.org/10.1006/abbi.2000.1932" @default.
• W2067214912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10933889" @default.
• W2067214912 hasPublicationYear "2000" @default.
• W2067214912 type Work @default.
• W2067214912 sameAs 2067214912 @default.
• W2067214912 citedByCount "7" @default.
• W2067214912 countsByYear W20672149122012 @default.
• W2067214912 countsByYear W20672149122013 @default.
• W2067214912 crossrefType "journal-article" @default.
• W2067214912 hasAuthorship W2067214912A5016361659 @default.
• W2067214912 hasAuthorship W2067214912A5037340003 @default.
• W2067214912 hasAuthorship W2067214912A5054673383 @default.
• W2067214912 hasAuthorship W2067214912A5059484191 @default.
• W2067214912 hasAuthorship W2067214912A5060555023 @default.
• W2067214912 hasAuthorship W2067214912A5071822877 @default.
• W2067214912 hasConcept C104317684 @default.
• W2067214912 hasConcept C107824862 @default.
• W2067214912 hasConcept C120197328 @default.
• W2067214912 hasConcept C128821507 @default.
• W2067214912 hasConcept C1292079 @default.
• W2067214912 hasConcept C185592680 @default.
• W2067214912 hasConcept C2775954498 @default.
• W2067214912 hasConcept C2781121885 @default.
• W2067214912 hasConcept C55493867 @default.
• W2067214912 hasConcept C63932345 @default.
• W2067214912 hasConcept C71240020 @default.
• W2067214912 hasConcept C86339819 @default.
• W2067214912 hasConcept C86803240 @default.
• W2067214912 hasConceptScore W2067214912C104317684 @default.
• W2067214912 hasConceptScore W2067214912C107824862 @default.
• W2067214912 hasConceptScore W2067214912C120197328 @default.
• W2067214912 hasConceptScore W2067214912C128821507 @default.
• W2067214912 hasConceptScore W2067214912C1292079 @default.
• W2067214912 hasConceptScore W2067214912C185592680 @default.
• W2067214912 hasConceptScore W2067214912C2775954498 @default.
• W2067214912 hasConceptScore W2067214912C2781121885 @default.
• W2067214912 hasConceptScore W2067214912C55493867 @default.
• W2067214912 hasConceptScore W2067214912C63932345 @default.
• W2067214912 hasConceptScore W2067214912C71240020 @default.
• W2067214912 hasConceptScore W2067214912C86339819 @default.
• W2067214912 hasConceptScore W2067214912C86803240 @default.
• W2067214912 hasIssue "2" @default.
• W2067214912 hasLocation W20672149121 @default.
• W2067214912 hasLocation W20672149122 @default.
• W2067214912 hasOpenAccess W2067214912 @default.
• W2067214912 hasPrimaryLocation W20672149121 @default.
• W2067214912 hasRelatedWork W1852623435 @default.
• W2067214912 hasRelatedWork W1984899370 @default.
• W2067214912 hasRelatedWork W2012761399 @default.
• W2067214912 hasRelatedWork W2051759589 @default.
• W2067214912 hasRelatedWork W2064107256 @default.
• W2067214912 hasRelatedWork W2102191600 @default.
• W2067214912 hasRelatedWork W2416520376 @default.

• next