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• W2067219613 abstract "The effect of a series of physostigmine analogs on acetylcholinesterase activity was investigated. The second-order rate constant k(on) of the enzyme-inhibitor complex correlates with the conformational positioning of aromatic residues, especially Trp84, in the transition state complex. The van der Waals interactions are an important structural element of this conformational change. A transient mobility of the cysteine loop (Cys67-Cys94) was confined only to the presence of a significant steric effect. Even with this limitation, however, the steric effect seems to be an appropriate model for future tests on the back door hypothesis involving facilitated opening for faster product clearance." @default.
• W2067219613 created "2016-06-24" @default.
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• W2067219613 date "2002-01-01" @default.
• W2067219613 modified "2023-09-26" @default.
• W2067219613 title "Inhibition of acetylcholinesterase by physostigmine analogs: Conformational mobility of cysteine loop due to the steric effect of the alkyl chain" @default.
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• W2067219613 doi "https://doi.org/10.1002/jbt.10026" @default.
• W2067219613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11979423" @default.
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