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- W2067222013 abstract "More than 5% of Caucasians carry a defective allele of the HFE gene, and one in 300 individuals has both alleles mutated and is, therefore, genetically predisposed to the iron-overload disorder known as idiopathic hemochromatosis1. Normally, iron stores in the organism are controlled by tuning intestinal iron absorption to the body's demand for iron. Such regulation is defective in hemochromatosis. Patients absorb two- to three-fold more iron than is normal from food, and the metal accumulates in the liver, the pancreas and heart muscle. The disorder manifests itself mainly in men of >40 years of age and provokes liver cirrhosis, diabetes and/or heart failure." @default.
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- W2067222013 date "1999-05-01" @default.
- W2067222013 modified "2023-09-25" @default.
- W2067222013 title "Iron overload: molecular clues to its cause" @default.
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- W2067222013 doi "https://doi.org/10.1016/s0968-0004(99)01386-9" @default.
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