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• W2067222383 abstract "Polyomavirus-associated nephropathy (PVAN) is an emerging cause of kidney transplant failure affecting 1-10% of patients. As uncertainty exists regarding risk factors, diagnosis, and intervention, an independent panel of experts reviewed the currently available evidence and prepared this report. Most cases of PVAN are elicited by BK virus (BKV) in the context of intense immunosuppression. No specific immunosuppressive drug is exclusively associated with PVAN, but most cases reported to date arise while the patient is on triple immunosuppressive combinations, often comprising tacrolimus and/or mycophenolate mofetil plus corticosteroids. Immunologic control of polyomavirus replication can be achieved by reducing, switching, and/or discontinuing components of the immunosuppressive regimen, but the individual's risk of rejection should be considered. The success rate of this intervention is increased with earlier diagnosis. Therefore, it is recommended that all renal transplant recipients should be screened for BKV replication in the urine: 1) every three months during the first two years posttransplant; 2) when allograft dysfunction is noted; and 3) when allograft biopsy is performed. A positive screening result should be confirmed in <4 weeks and assessed by quantitative assays (e.g. BKV DNA or RNA load in plasma or urine). Definitive diagnosis of PVAN requires allograft biopsy. If PVAN and concurrent acute rejection is diagnosed, antirejection treatment should be considered, coupled with subsequently reducing immunosuppression. The antiviral cidofovir is not approved for PVAN, but investigational use at low doses (0.25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication." @default.
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• W2067222383 date "2005-05-27" @default.
• W2067222383 modified "2023-10-18" @default.
• W2067222383 title "Polyomavirus-Associated Nephropathy in Renal Transplantation: Interdisciplinary Analyses and Recommendations" @default.
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• W2067222383 cites W1966975760 @default.
• W2067222383 cites W1970342204 @default.
• W2067222383 cites W1970947525 @default.
• W2067222383 cites W1974085494 @default.
• W2067222383 cites W1977093612 @default.
• W2067222383 cites W1979902564 @default.
• W2067222383 cites W1981423038 @default.
• W2067222383 cites W1989096394 @default.
• W2067222383 cites W1989764901 @default.
• W2067222383 cites W1992111631 @default.
• W2067222383 cites W1992403086 @default.
• W2067222383 cites W1995791071 @default.
• W2067222383 cites W1996438558 @default.
• W2067222383 cites W2002394651 @default.
• W2067222383 cites W2007574963 @default.
• W2067222383 cites W2008849494 @default.
• W2067222383 cites W2008892938 @default.
• W2067222383 cites W2009992204 @default.
• W2067222383 cites W2011037252 @default.
• W2067222383 cites W2012460318 @default.
• W2067222383 cites W2014119693 @default.
• W2067222383 cites W2021883795 @default.
• W2067222383 cites W2026651427 @default.
• W2067222383 cites W2035597292 @default.
• W2067222383 cites W2041354789 @default.
• W2067222383 cites W2041618865 @default.
• W2067222383 cites W2042871247 @default.
• W2067222383 cites W2046462591 @default.
• W2067222383 cites W2047305338 @default.
• W2067222383 cites W2048704277 @default.
• W2067222383 cites W2052563577 @default.
• W2067222383 cites W2055602856 @default.
• W2067222383 cites W2058517307 @default.
• W2067222383 cites W2059703775 @default.
• W2067222383 cites W2063071979 @default.
• W2067222383 cites W2064504844 @default.
• W2067222383 cites W2066679010 @default.
• W2067222383 cites W2067573171 @default.
• W2067222383 cites W2074350514 @default.
• W2067222383 cites W2075118035 @default.
• W2067222383 cites W2076997943 @default.
• W2067222383 cites W2078044732 @default.
• W2067222383 cites W2081384054 @default.
• W2067222383 cites W2086053455 @default.
• W2067222383 cites W2088168913 @default.
• W2067222383 cites W2089017407 @default.
• W2067222383 cites W2093934336 @default.
• W2067222383 cites W2097389207 @default.
• W2067222383 cites W2097956063 @default.
• W2067222383 cites W2105823869 @default.
• W2067222383 cites W2107610513 @default.
• W2067222383 cites W2110079652 @default.
• W2067222383 cites W2113062040 @default.
• W2067222383 cites W2115772837 @default.
• W2067222383 cites W2116867113 @default.
• W2067222383 cites W2120744979 @default.
• W2067222383 cites W2124346303 @default.
• W2067222383 cites W2128074729 @default.
• W2067222383 cites W2135813995 @default.
• W2067222383 cites W2159856736 @default.
• W2067222383 cites W2164993846 @default.
• W2067222383 cites W2312792525 @default.
• W2067222383 cites W2409144863 @default.
• W2067222383 cites W4211003049 @default.
• W2067222383 cites W4248102370 @default.
• W2067222383 cites W4251273209 @default.
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• W2067222383 doi "https://doi.org/10.1097/01.tp.0000156165.83160.09" @default.
• W2067222383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15912088" @default.
• W2067222383 hasPublicationYear "2005" @default.
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