Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067222711> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2067222711 endingPage "125" @default.
- W2067222711 startingPage "118" @default.
- W2067222711 abstract "Previous publications from this laboratory have demonstrated that agents such as methotrexate (MTX), 5-fluorodeoxyuridine (FUdR), trimethoprim, and D-glucosamine (D-GlcN), which are known to inhibit thymidylate synthesis, can augment human NK activity in vitro. Further-more, this augmentation was inhibited by exogenous thymidine (TdR) at concentrations of 10−6 to 10−7M. In this report, underlying mechanisms of action of FUdR, D-GlcN, and IFN are compared. Each of these agents increased the lytic activity of effector cells bound to targets but did not increase the percentage of conjugates formed. The augmentation could be induced in a population highly enriched for NK cells (Leu-11b positive in phenotype). FUdR and D-GlcN could not induce any augmentation in a Leu-11b-negative subpopulation whereas IFN could induce significant lytic activity. α-Amanitin, an inhibitor of RNA polymerase II, blocked the activation of NK activity by all three reagents; hence gene expression was required. Comparison of [35S]methionine-labeled proteins by two-dimensional gel electrophoresis revealed that six new proteins were induced in IFN-treated cells. Three of these were similar in pI and molecular weight to the newly synthesized proteins in the D-GlcN-treated cells. One protein was synthesized in increased amounts in the FUdR-treated cells and it was not common to either of the other treatments. Evidence to date is consistent with the hypothesis that separate mechanisms underlie the activation of NK cells by IFN and thymidylate synthesis inhibitors, although the existence of a final common pathway for all NK response modulators cannot be excluded at the present time." @default.
- W2067222711 created "2016-06-24" @default.
- W2067222711 creator A5016411654 @default.
- W2067222711 creator A5018351485 @default.
- W2067222711 creator A5050633445 @default.
- W2067222711 creator A5075631366 @default.
- W2067222711 date "1988-01-01" @default.
- W2067222711 modified "2023-09-25" @default.
- W2067222711 title "Studies on the mechanism of activation of human natural killer function by interferon and inhibitors of thymidylate synthesis" @default.
- W2067222711 cites W1484858601 @default.
- W2067222711 cites W1544808474 @default.
- W2067222711 cites W1549447242 @default.
- W2067222711 cites W1606423922 @default.
- W2067222711 cites W1993319836 @default.
- W2067222711 cites W2004616454 @default.
- W2067222711 cites W2047777355 @default.
- W2067222711 cites W2088740471 @default.
- W2067222711 cites W4313313358 @default.
- W2067222711 doi "https://doi.org/10.1016/0008-8749(88)90056-1" @default.
- W2067222711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2448044" @default.
- W2067222711 hasPublicationYear "1988" @default.
- W2067222711 type Work @default.
- W2067222711 sameAs 2067222711 @default.
- W2067222711 citedByCount "11" @default.
- W2067222711 crossrefType "journal-article" @default.
- W2067222711 hasAuthorship W2067222711A5016411654 @default.
- W2067222711 hasAuthorship W2067222711A5018351485 @default.
- W2067222711 hasAuthorship W2067222711A5050633445 @default.
- W2067222711 hasAuthorship W2067222711A5075631366 @default.
- W2067222711 hasConcept C123321153 @default.
- W2067222711 hasConcept C144024400 @default.
- W2067222711 hasConcept C149923435 @default.
- W2067222711 hasConcept C153911025 @default.
- W2067222711 hasConcept C182615771 @default.
- W2067222711 hasConcept C202751555 @default.
- W2067222711 hasConcept C203014093 @default.
- W2067222711 hasConcept C2522874641 @default.
- W2067222711 hasConcept C2776694085 @default.
- W2067222711 hasConcept C2777108182 @default.
- W2067222711 hasConcept C2780456651 @default.
- W2067222711 hasConcept C2780912031 @default.
- W2067222711 hasConcept C2908647359 @default.
- W2067222711 hasConcept C515207424 @default.
- W2067222711 hasConcept C51785407 @default.
- W2067222711 hasConcept C54355233 @default.
- W2067222711 hasConcept C55493867 @default.
- W2067222711 hasConcept C86803240 @default.
- W2067222711 hasConceptScore W2067222711C123321153 @default.
- W2067222711 hasConceptScore W2067222711C144024400 @default.
- W2067222711 hasConceptScore W2067222711C149923435 @default.
- W2067222711 hasConceptScore W2067222711C153911025 @default.
- W2067222711 hasConceptScore W2067222711C182615771 @default.
- W2067222711 hasConceptScore W2067222711C202751555 @default.
- W2067222711 hasConceptScore W2067222711C203014093 @default.
- W2067222711 hasConceptScore W2067222711C2522874641 @default.
- W2067222711 hasConceptScore W2067222711C2776694085 @default.
- W2067222711 hasConceptScore W2067222711C2777108182 @default.
- W2067222711 hasConceptScore W2067222711C2780456651 @default.
- W2067222711 hasConceptScore W2067222711C2780912031 @default.
- W2067222711 hasConceptScore W2067222711C2908647359 @default.
- W2067222711 hasConceptScore W2067222711C515207424 @default.
- W2067222711 hasConceptScore W2067222711C51785407 @default.
- W2067222711 hasConceptScore W2067222711C54355233 @default.
- W2067222711 hasConceptScore W2067222711C55493867 @default.
- W2067222711 hasConceptScore W2067222711C86803240 @default.
- W2067222711 hasIssue "1" @default.
- W2067222711 hasLocation W20672227111 @default.
- W2067222711 hasLocation W20672227112 @default.
- W2067222711 hasOpenAccess W2067222711 @default.
- W2067222711 hasPrimaryLocation W20672227111 @default.
- W2067222711 hasRelatedWork W1213032464 @default.
- W2067222711 hasRelatedWork W1485505865 @default.
- W2067222711 hasRelatedWork W1541632951 @default.
- W2067222711 hasRelatedWork W1972284489 @default.
- W2067222711 hasRelatedWork W1980675650 @default.
- W2067222711 hasRelatedWork W2022047627 @default.
- W2067222711 hasRelatedWork W2037288319 @default.
- W2067222711 hasRelatedWork W2050470473 @default.
- W2067222711 hasRelatedWork W2067222711 @default.
- W2067222711 hasRelatedWork W2416442925 @default.
- W2067222711 hasVolume "111" @default.
- W2067222711 isParatext "false" @default.
- W2067222711 isRetracted "false" @default.
- W2067222711 magId "2067222711" @default.
- W2067222711 workType "article" @default.