Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067223216> ?p ?o ?g. }
- W2067223216 endingPage "232" @default.
- W2067223216 startingPage "224" @default.
- W2067223216 abstract "Abstract Hypoxia is common to several inflammatory diseases, where multiple cell types release adenine-nucleotides (particularly adenosine triphosphate/adenosine diphosphate). Adenosine triphosphate/adenosine diphosphate is metabolized to adenosine through a 2-step enzymatic reaction initiated by CD39 (ectonucleoside-triphosphate-diphosphohydrolase-1). Thus, extracellular adenosine becomes available to regulate multiple inflammatory endpoints. Here, we hypothesized that hypoxia transcriptionally up-regulates CD39 expression. Initial studies revealed hypoxia-dependent increases in CD39 mRNA and immunoreactivity on endothelia. Examination of the human CD39 gene promoter identified a region important in hypoxia inducibility. Multiple levels of analysis, including site-directed mutagenesis, chromatin immunoprecipitation, and inhibition by antisense, revealed a critical role for transcription-factor Sp1 in hypoxia-induction of CD39. Using a combination of cd39−/− mice and Sp1 small interfering RNA in in vivo cardiac ischemia models revealed Sp1-mediated induction of cardiac CD39 during myocardial ischemia. In summary, these results identify a novel Sp1-dependent regulatory pathway for CD39 and indicate the likelihood that CD39 is central to protective responses to hypoxia/ischemia." @default.
- W2067223216 created "2016-06-24" @default.
- W2067223216 creator A5001509341 @default.
- W2067223216 creator A5041621533 @default.
- W2067223216 creator A5049650132 @default.
- W2067223216 creator A5053050817 @default.
- W2067223216 creator A5058382756 @default.
- W2067223216 creator A5076586800 @default.
- W2067223216 date "2009-01-01" @default.
- W2067223216 modified "2023-10-02" @default.
- W2067223216 title "Central role of Sp1-regulated CD39 in hypoxia/ischemia protection" @default.
- W2067223216 cites W1492226152 @default.
- W2067223216 cites W1522010565 @default.
- W2067223216 cites W1565285014 @default.
- W2067223216 cites W1968040201 @default.
- W2067223216 cites W1979024995 @default.
- W2067223216 cites W1979191748 @default.
- W2067223216 cites W1985407729 @default.
- W2067223216 cites W1988951550 @default.
- W2067223216 cites W1990113288 @default.
- W2067223216 cites W1991607763 @default.
- W2067223216 cites W1997931717 @default.
- W2067223216 cites W2000272522 @default.
- W2067223216 cites W2001189110 @default.
- W2067223216 cites W2002451448 @default.
- W2067223216 cites W2002566701 @default.
- W2067223216 cites W2002978565 @default.
- W2067223216 cites W2014023264 @default.
- W2067223216 cites W2020809562 @default.
- W2067223216 cites W2025605461 @default.
- W2067223216 cites W2033851444 @default.
- W2067223216 cites W2041292257 @default.
- W2067223216 cites W2046429224 @default.
- W2067223216 cites W2049505878 @default.
- W2067223216 cites W2051904995 @default.
- W2067223216 cites W2056222368 @default.
- W2067223216 cites W2060927696 @default.
- W2067223216 cites W2068019817 @default.
- W2067223216 cites W2088627897 @default.
- W2067223216 cites W2089916504 @default.
- W2067223216 cites W2092509331 @default.
- W2067223216 cites W2106169455 @default.
- W2067223216 cites W2116238347 @default.
- W2067223216 cites W2117282734 @default.
- W2067223216 cites W2117637600 @default.
- W2067223216 cites W2121815506 @default.
- W2067223216 cites W2125505202 @default.
- W2067223216 cites W2132700592 @default.
- W2067223216 cites W2133068443 @default.
- W2067223216 cites W2138216041 @default.
- W2067223216 cites W2141035582 @default.
- W2067223216 cites W2159138195 @default.
- W2067223216 cites W2163927795 @default.
- W2067223216 cites W2164266560 @default.
- W2067223216 cites W2166798770 @default.
- W2067223216 cites W2169661250 @default.
- W2067223216 cites W2170936621 @default.
- W2067223216 cites W2171678969 @default.
- W2067223216 cites W4229980946 @default.
- W2067223216 cites W4318373325 @default.
- W2067223216 doi "https://doi.org/10.1182/blood-2008-06-165746" @default.
- W2067223216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2614635" @default.
- W2067223216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18812468" @default.
- W2067223216 hasPublicationYear "2009" @default.
- W2067223216 type Work @default.
- W2067223216 sameAs 2067223216 @default.
- W2067223216 citedByCount "196" @default.
- W2067223216 countsByYear W20672232162012 @default.
- W2067223216 countsByYear W20672232162013 @default.
- W2067223216 countsByYear W20672232162014 @default.
- W2067223216 countsByYear W20672232162015 @default.
- W2067223216 countsByYear W20672232162016 @default.
- W2067223216 countsByYear W20672232162017 @default.
- W2067223216 countsByYear W20672232162018 @default.
- W2067223216 countsByYear W20672232162019 @default.
- W2067223216 countsByYear W20672232162020 @default.
- W2067223216 countsByYear W20672232162021 @default.
- W2067223216 countsByYear W20672232162022 @default.
- W2067223216 countsByYear W20672232162023 @default.
- W2067223216 crossrefType "journal-article" @default.
- W2067223216 hasAuthorship W2067223216A5001509341 @default.
- W2067223216 hasAuthorship W2067223216A5041621533 @default.
- W2067223216 hasAuthorship W2067223216A5049650132 @default.
- W2067223216 hasAuthorship W2067223216A5053050817 @default.
- W2067223216 hasAuthorship W2067223216A5058382756 @default.
- W2067223216 hasAuthorship W2067223216A5076586800 @default.
- W2067223216 hasBestOaLocation W20672232161 @default.
- W2067223216 hasConcept C101762097 @default.
- W2067223216 hasConcept C104317684 @default.
- W2067223216 hasConcept C134018914 @default.
- W2067223216 hasConcept C134320426 @default.
- W2067223216 hasConcept C150194340 @default.
- W2067223216 hasConcept C153911025 @default.
- W2067223216 hasConcept C178790620 @default.
- W2067223216 hasConcept C185592680 @default.
- W2067223216 hasConcept C22615655 @default.
- W2067223216 hasConcept C2776991684 @default.
- W2067223216 hasConcept C2779564974 @default.