FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067225141> ?p ?o ?g. }

• W2067225141 endingPage "148" @default.
• W2067225141 startingPage "143" @default.
• W2067225141 abstract "Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. Although the generally accepted definition includes three domains of symptoms (variable airway obstruction, airway hyper-responsiveness, and airway inflammation), there is general agreement that, rather than being a single disease entity, asthma consists of related, overlapping syndromes. A considerable proportion of asthma is IgE-mediated, but the observation that not all individuals with asthma are atopic adds to the heterogeneity. Although a genetic basis for asthma is undeniable, elucidation of polymorphisms that are causal is greatly hampered by variability in the clinical phenotype, which is likely due to the multiple molecular mechanisms underlying the complex pathological processes involved in disease development and progression. One objective of this review is to consider progress that has been made to date in gene discovery in the field of asthma, with a focus on the evolution of molecular genetic methods that have led to the discoveries thus far, and with a particular focus on the major advances owed to the published genome-wide association studies (GWAS) on asthma to date. A second objective is to consider a Darwinian approach toward understanding the genetic underpinnings of asthma, including evidence supporting a modified Hygiene Hypothesis, which suggests that there are co-associations between asthma risk polymorphisms and polymorphisms associated with another IgE-mediated disease, schistosomiasis. The overall conclusion is that the huge research efforts and expense committed to asthma genetics have changed the perception about disease etiology in general and the functional relevance of the asthma genes identified thus far in particular." @default.
• W2067225141 created "2016-06-24" @default.
• W2067225141 creator A5008575529 @default.
• W2067225141 date "2011-05-01" @default.
• W2067225141 modified "2023-09-25" @default.
• W2067225141 title "Genetic Studies of the Etiology of Asthma" @default.
• W2067225141 cites W1515527087 @default.
• W2067225141 cites W1519085294 @default.
• W2067225141 cites W1549918021 @default.
• W2067225141 cites W1939593001 @default.
• W2067225141 cites W1965075555 @default.
• W2067225141 cites W1969788366 @default.
• W2067225141 cites W1972635337 @default.
• W2067225141 cites W1974386465 @default.
• W2067225141 cites W1976131363 @default.
• W2067225141 cites W1978433253 @default.
• W2067225141 cites W1979429463 @default.
• W2067225141 cites W1982042604 @default.
• W2067225141 cites W1985457114 @default.
• W2067225141 cites W1996879998 @default.
• W2067225141 cites W1997856674 @default.
• W2067225141 cites W2008599922 @default.
• W2067225141 cites W2016258379 @default.
• W2067225141 cites W2024611468 @default.
• W2067225141 cites W2026386906 @default.
• W2067225141 cites W2033559006 @default.
• W2067225141 cites W2034687927 @default.
• W2067225141 cites W2038059657 @default.
• W2067225141 cites W2040450387 @default.
• W2067225141 cites W2046925806 @default.
• W2067225141 cites W2049602257 @default.
• W2067225141 cites W2051633434 @default.
• W2067225141 cites W2055349211 @default.
• W2067225141 cites W2057436414 @default.
• W2067225141 cites W2058792575 @default.
• W2067225141 cites W2058836799 @default.
• W2067225141 cites W2060846383 @default.
• W2067225141 cites W2062776833 @default.
• W2067225141 cites W2063097062 @default.
• W2067225141 cites W2066597044 @default.
• W2067225141 cites W2067564501 @default.
• W2067225141 cites W2068397590 @default.
• W2067225141 cites W2068807890 @default.
• W2067225141 cites W2072063345 @default.
• W2067225141 cites W2078050848 @default.
• W2067225141 cites W2084550566 @default.
• W2067225141 cites W2084709665 @default.
• W2067225141 cites W2087232033 @default.
• W2067225141 cites W2088717960 @default.
• W2067225141 cites W2090704292 @default.
• W2067225141 cites W2092987741 @default.
• W2067225141 cites W2100748655 @default.
• W2067225141 cites W2102377602 @default.
• W2067225141 cites W2104775278 @default.
• W2067225141 cites W2106632568 @default.
• W2067225141 cites W2106852187 @default.
• W2067225141 cites W2113624460 @default.
• W2067225141 cites W2118643159 @default.
• W2067225141 cites W2119163963 @default.
• W2067225141 cites W2120471388 @default.
• W2067225141 cites W2122895864 @default.
• W2067225141 cites W2129316818 @default.
• W2067225141 cites W2129656249 @default.
• W2067225141 cites W2130684872 @default.
• W2067225141 cites W2133426798 @default.
• W2067225141 cites W2133739312 @default.
• W2067225141 cites W2135298542 @default.
• W2067225141 cites W2149054550 @default.
• W2067225141 cites W2154156503 @default.
• W2067225141 cites W2158206794 @default.
• W2067225141 cites W2159556553 @default.
• W2067225141 cites W2162300141 @default.
• W2067225141 cites W2165277651 @default.
• W2067225141 cites W2170248047 @default.
• W2067225141 cites W2325173010 @default.
• W2067225141 cites W387031605 @default.
• W2067225141 doi "https://doi.org/10.1513/pats.201103-030ms" @default.
• W2067225141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131830" @default.
• W2067225141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21543791" @default.
• W2067225141 hasPublicationYear "2011" @default.
• W2067225141 type Work @default.
• W2067225141 sameAs 2067225141 @default.
• W2067225141 citedByCount "32" @default.
• W2067225141 countsByYear W20672251412012 @default.
• W2067225141 countsByYear W20672251412013 @default.
• W2067225141 countsByYear W20672251412014 @default.
• W2067225141 countsByYear W20672251412015 @default.
• W2067225141 countsByYear W20672251412016 @default.
• W2067225141 countsByYear W20672251412017 @default.
• W2067225141 countsByYear W20672251412018 @default.
• W2067225141 countsByYear W20672251412019 @default.
• W2067225141 countsByYear W20672251412020 @default.
• W2067225141 countsByYear W20672251412021 @default.
• W2067225141 countsByYear W20672251412022 @default.
• W2067225141 crossrefType "journal-article" @default.
• W2067225141 hasAuthorship W2067225141A5008575529 @default.
• W2067225141 hasBestOaLocation W20672251412 @default.
• W2067225141 hasConcept C104317684 @default.

• next