FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067227935> ?p ?o ?g. }

• W2067227935 endingPage "1110" @default.
• W2067227935 startingPage "1105" @default.
• W2067227935 abstract "This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism. New evidence at the molecular and cellular level suggests that acamprosate attenuates hyper-glutamatergic states that occur during early abstinence and involves iono (NMDA)- and metabotrotropic (mGluR5) glutamate receptors along with augmented intracellular calcium release and electrophysiological changes. Thus mutant mice with enhanced glutamate levels exhibit higher alcohol consumption than wild type mice and respond better to acamprosate, demonstrating that acamprosate acts mainly on a hyper-glutamatergic system. This mode of action further suggests that acamprosate exhibits neuroprotective properties. In rats, cue-induced reinstatement behavior is significantly reduced by acamprosate treatment whereas cue-induced craving responses in alcohol-dependent patients seem not to be affected by this treatment. An ongoing study (Project Predict) defines specific responder profiles for an individualized use of acamprosate and naltrexone. Neurophysiological as well as psychometric data are used to define 2 groups of patients: reward cravers and relief cravers. While naltrexone should work better in the first group, acamprosate is hypothesized to be efficacious in the latter where withdrawal associated and/or cue induced hyper-glutamatergic states are thought to trigger relapse. Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy." @default.
• W2067227935 created "2016-06-24" @default.
• W2067227935 creator A5016315764 @default.
• W2067227935 creator A5052690237 @default.
• W2067227935 creator A5057131258 @default.
• W2067227935 creator A5058409050 @default.
• W2067227935 date "2008-06-28" @default.
• W2067227935 modified "2023-10-17" @default.
• W2067227935 title "Acamprosate: Recent Findings and Future Research Directions" @default.
• W2067227935 cites W1913760354 @default.
• W2067227935 cites W1965051624 @default.
• W2067227935 cites W1978411103 @default.
• W2067227935 cites W1978571756 @default.
• W2067227935 cites W1982903386 @default.
• W2067227935 cites W1985180181 @default.
• W2067227935 cites W1991716748 @default.
• W2067227935 cites W1992093536 @default.
• W2067227935 cites W1999081649 @default.
• W2067227935 cites W2002376565 @default.
• W2067227935 cites W2003377853 @default.
• W2067227935 cites W2005949458 @default.
• W2067227935 cites W2011830495 @default.
• W2067227935 cites W2013124619 @default.
• W2067227935 cites W2013882814 @default.
• W2067227935 cites W2016004429 @default.
• W2067227935 cites W2023418630 @default.
• W2067227935 cites W2029167262 @default.
• W2067227935 cites W2032685526 @default.
• W2067227935 cites W2033122986 @default.
• W2067227935 cites W2037926031 @default.
• W2067227935 cites W2041018266 @default.
• W2067227935 cites W2042119083 @default.
• W2067227935 cites W2051008105 @default.
• W2067227935 cites W2055482245 @default.
• W2067227935 cites W2056610139 @default.
• W2067227935 cites W2059402504 @default.
• W2067227935 cites W2060329826 @default.
• W2067227935 cites W2063996581 @default.
• W2067227935 cites W2071761663 @default.
• W2067227935 cites W2074075381 @default.
• W2067227935 cites W2076682630 @default.
• W2067227935 cites W2082703403 @default.
• W2067227935 cites W2084072489 @default.
• W2067227935 cites W2101372918 @default.
• W2067227935 cites W2101436564 @default.
• W2067227935 cites W2109034809 @default.
• W2067227935 cites W2112606475 @default.
• W2067227935 cites W2121596468 @default.
• W2067227935 cites W2125595361 @default.
• W2067227935 cites W2126519871 @default.
• W2067227935 cites W2127482905 @default.
• W2067227935 cites W2136871251 @default.
• W2067227935 cites W2138524791 @default.
• W2067227935 cites W2140395780 @default.
• W2067227935 cites W2140948213 @default.
• W2067227935 cites W2157113531 @default.
• W2067227935 cites W2163016994 @default.
• W2067227935 cites W4230396476 @default.
• W2067227935 cites W4234336670 @default.
• W2067227935 cites W4245865968 @default.
• W2067227935 doi "https://doi.org/10.1111/j.1530-0277.2008.00690.x" @default.
• W2067227935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18540918" @default.
• W2067227935 hasPublicationYear "2008" @default.
• W2067227935 type Work @default.
• W2067227935 sameAs 2067227935 @default.
• W2067227935 citedByCount "154" @default.
• W2067227935 countsByYear W20672279352012 @default.
• W2067227935 countsByYear W20672279352013 @default.
• W2067227935 countsByYear W20672279352014 @default.
• W2067227935 countsByYear W20672279352015 @default.
• W2067227935 countsByYear W20672279352016 @default.
• W2067227935 countsByYear W20672279352017 @default.
• W2067227935 countsByYear W20672279352018 @default.
• W2067227935 countsByYear W20672279352019 @default.
• W2067227935 countsByYear W20672279352020 @default.
• W2067227935 countsByYear W20672279352021 @default.
• W2067227935 countsByYear W20672279352022 @default.
• W2067227935 countsByYear W20672279352023 @default.
• W2067227935 crossrefType "journal-article" @default.
• W2067227935 hasAuthorship W2067227935A5016315764 @default.
• W2067227935 hasAuthorship W2067227935A5052690237 @default.
• W2067227935 hasAuthorship W2067227935A5057131258 @default.
• W2067227935 hasAuthorship W2067227935A5058409050 @default.
• W2067227935 hasConcept C118552586 @default.
• W2067227935 hasConcept C126322002 @default.
• W2067227935 hasConcept C15744967 @default.
• W2067227935 hasConcept C169760540 @default.
• W2067227935 hasConcept C170493617 @default.
• W2067227935 hasConcept C25498285 @default.
• W2067227935 hasConcept C2776885963 @default.
• W2067227935 hasConcept C2777972943 @default.
• W2067227935 hasConcept C2779541405 @default.
• W2067227935 hasConcept C2779992327 @default.
• W2067227935 hasConcept C2780648746 @default.
• W2067227935 hasConcept C2781089641 @default.
• W2067227935 hasConcept C41653306 @default.
• W2067227935 hasConcept C48856860 @default.
• W2067227935 hasConcept C49051014 @default.

• next