Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067232259> ?p ?o ?g. }
- W2067232259 endingPage "311" @default.
- W2067232259 startingPage "306" @default.
- W2067232259 abstract "Hypoxia generated in tumors has been shown to contribute to mutations and genetic instability. However, the molecular mechanisms remain incompletely defined. Since reactive oxygen species (ROS) are overproduced immediately after reoxygenation of hypoxic cells and generate oxidized guanine, we assumed that the mechanisms might involve translesion DNA polymerases that can bypass oxidized guanine. We report here that hypoxia as well as hypoxia mimetics, desferrioxamine, and CoCl2, enhanced the expression of DNA polymerase ι (pol ι) in human tumor cell lines. Searching the consensus sequence of hypoxia response element to which HIF-1 binds revealed that it locates in the intron 1 of the pol ι gene. These results suggest that HIF-1-mediated pol ι gene expression may be involved in the generation of translesion mutations during DNA replication after hypoxia followed by reoxygenation, thereby contributing to the accumulation of genetic changes in tumor cells." @default.
- W2067232259 created "2016-06-24" @default.
- W2067232259 creator A5046840239 @default.
- W2067232259 creator A5064567826 @default.
- W2067232259 creator A5073191659 @default.
- W2067232259 creator A5073348980 @default.
- W2067232259 creator A5079085877 @default.
- W2067232259 date "2006-12-01" @default.
- W2067232259 modified "2023-10-01" @default.
- W2067232259 title "Hypoxia-inducible factor-1 mediates the expression of DNA polymerase ι in human tumor cells" @default.
- W2067232259 cites W1493048246 @default.
- W2067232259 cites W1545825939 @default.
- W2067232259 cites W1642306226 @default.
- W2067232259 cites W1908705633 @default.
- W2067232259 cites W1937401270 @default.
- W2067232259 cites W1985118104 @default.
- W2067232259 cites W2010394923 @default.
- W2067232259 cites W2017626786 @default.
- W2067232259 cites W2026768632 @default.
- W2067232259 cites W2029353661 @default.
- W2067232259 cites W2046884413 @default.
- W2067232259 cites W2047688922 @default.
- W2067232259 cites W2072227408 @default.
- W2067232259 cites W2075054245 @default.
- W2067232259 cites W2078840215 @default.
- W2067232259 cites W2095301528 @default.
- W2067232259 cites W2096551220 @default.
- W2067232259 cites W2111983416 @default.
- W2067232259 cites W2112864654 @default.
- W2067232259 cites W2115568198 @default.
- W2067232259 cites W2120053712 @default.
- W2067232259 cites W2130548814 @default.
- W2067232259 cites W2142513910 @default.
- W2067232259 cites W2142998699 @default.
- W2067232259 cites W2152950651 @default.
- W2067232259 cites W4210994720 @default.
- W2067232259 doi "https://doi.org/10.1016/j.bbrc.2006.10.048" @default.
- W2067232259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17056006" @default.
- W2067232259 hasPublicationYear "2006" @default.
- W2067232259 type Work @default.
- W2067232259 sameAs 2067232259 @default.
- W2067232259 citedByCount "17" @default.
- W2067232259 countsByYear W20672322592013 @default.
- W2067232259 countsByYear W20672322592015 @default.
- W2067232259 countsByYear W20672322592016 @default.
- W2067232259 countsByYear W20672322592017 @default.
- W2067232259 countsByYear W20672322592019 @default.
- W2067232259 countsByYear W20672322592020 @default.
- W2067232259 countsByYear W20672322592021 @default.
- W2067232259 countsByYear W20672322592023 @default.
- W2067232259 crossrefType "journal-article" @default.
- W2067232259 hasAuthorship W2067232259A5046840239 @default.
- W2067232259 hasAuthorship W2067232259A5064567826 @default.
- W2067232259 hasAuthorship W2067232259A5073191659 @default.
- W2067232259 hasAuthorship W2067232259A5073348980 @default.
- W2067232259 hasAuthorship W2067232259A5079085877 @default.
- W2067232259 hasConcept C104317684 @default.
- W2067232259 hasConcept C143425029 @default.
- W2067232259 hasConcept C150194340 @default.
- W2067232259 hasConcept C153911025 @default.
- W2067232259 hasConcept C2756471 @default.
- W2067232259 hasConcept C2778301229 @default.
- W2067232259 hasConcept C512185932 @default.
- W2067232259 hasConcept C54355233 @default.
- W2067232259 hasConcept C552990157 @default.
- W2067232259 hasConcept C82381507 @default.
- W2067232259 hasConcept C86803240 @default.
- W2067232259 hasConcept C95444343 @default.
- W2067232259 hasConceptScore W2067232259C104317684 @default.
- W2067232259 hasConceptScore W2067232259C143425029 @default.
- W2067232259 hasConceptScore W2067232259C150194340 @default.
- W2067232259 hasConceptScore W2067232259C153911025 @default.
- W2067232259 hasConceptScore W2067232259C2756471 @default.
- W2067232259 hasConceptScore W2067232259C2778301229 @default.
- W2067232259 hasConceptScore W2067232259C512185932 @default.
- W2067232259 hasConceptScore W2067232259C54355233 @default.
- W2067232259 hasConceptScore W2067232259C552990157 @default.
- W2067232259 hasConceptScore W2067232259C82381507 @default.
- W2067232259 hasConceptScore W2067232259C86803240 @default.
- W2067232259 hasConceptScore W2067232259C95444343 @default.
- W2067232259 hasIssue "1" @default.
- W2067232259 hasLocation W20672322591 @default.
- W2067232259 hasLocation W20672322592 @default.
- W2067232259 hasOpenAccess W2067232259 @default.
- W2067232259 hasPrimaryLocation W20672322591 @default.
- W2067232259 hasRelatedWork W1489886741 @default.
- W2067232259 hasRelatedWork W1968268301 @default.
- W2067232259 hasRelatedWork W1996781975 @default.
- W2067232259 hasRelatedWork W2009966535 @default.
- W2067232259 hasRelatedWork W2028633235 @default.
- W2067232259 hasRelatedWork W2055602243 @default.
- W2067232259 hasRelatedWork W2153880375 @default.
- W2067232259 hasRelatedWork W2462629497 @default.
- W2067232259 hasRelatedWork W2479578903 @default.
- W2067232259 hasRelatedWork W2187586729 @default.
- W2067232259 hasVolume "351" @default.
- W2067232259 isParatext "false" @default.
- W2067232259 isRetracted "false" @default.