Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067246066> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2067246066 endingPage "1322" @default.
- W2067246066 startingPage "1311" @default.
- W2067246066 abstract "Cholesterol is most often found distributed nonrandomly in the plane of the bilayer, giving rise to cholesterol-rich and -poor domains. Many of these domains are thought to be crucial for the maintenance of membrane structure and function. However, such well-characterized domains generally occur in the membranes that contain relatively large amounts of cholesterol. Cholesterol organization in membranes containing very low amounts of cholesterol has not been investigated extensively. Recent evidence from differential-scanning calorimetric studies suggest that cholesterol may not form uniform monodisperse solutions, as assumed earlier, in the membranes even at very low concentrations. Fluorescent cholesterol analogues, when chosen carefully, offer a powerful approach for studying the distribution and organization of cholesterol in membranes at low concentrations. In this paper, we have studied the organization of cholesterol in membranes at very low concentrations (up to 5 mol % of the total lipid) using a fluorescent cholesterol analogue (NBD-cholesterol) which is labeled with the 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) group at the flexible acyl chain, without any alteration in the structural features necessary for proper membrane incorporation. Our results show that NBD-cholesterol exhibits local organization even at very low concentrations. This is consistent with the recently suggested model of cholesterol organization in membranes at low concentrations, involving the formation of transbilayer, tail-to-tail dimers [Harris, J.S., Epps, D. E., Davio, S. R., & Kezdy, F.J. (1995) Biochemistry 34, 3851-3857]. The implications of such local cholesterol organization in membranes that have very low cholesterol content in vivo, such as the endoplasmic reticulum and the inner mitochondrial membrane, open up interesting possibilities." @default.
- W2067246066 created "2016-06-24" @default.
- W2067246066 creator A5031849699 @default.
- W2067246066 creator A5063835467 @default.
- W2067246066 date "1996-01-01" @default.
- W2067246066 modified "2023-10-18" @default.
- W2067246066 title "Membrane Organization at Low Cholesterol Concentrations: A Study Using 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-Labeled Cholesterol" @default.
- W2067246066 cites W1522819451 @default.
- W2067246066 cites W1595123479 @default.
- W2067246066 cites W1818223200 @default.
- W2067246066 cites W1965760487 @default.
- W2067246066 cites W1967630525 @default.
- W2067246066 cites W1982581544 @default.
- W2067246066 cites W2005897347 @default.
- W2067246066 cites W2007753996 @default.
- W2067246066 cites W2009144858 @default.
- W2067246066 cites W2017145860 @default.
- W2067246066 cites W2032496660 @default.
- W2067246066 cites W2042787593 @default.
- W2067246066 cites W2064754325 @default.
- W2067246066 cites W2068418997 @default.
- W2067246066 cites W2081393126 @default.
- W2067246066 cites W2086247286 @default.
- W2067246066 cites W2088459238 @default.
- W2067246066 cites W2099559490 @default.
- W2067246066 cites W2106508078 @default.
- W2067246066 cites W2111930154 @default.
- W2067246066 cites W2131115067 @default.
- W2067246066 cites W2187957429 @default.
- W2067246066 cites W4241922471 @default.
- W2067246066 cites W4299496276 @default.
- W2067246066 doi "https://doi.org/10.1021/bi951953q" @default.
- W2067246066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8573588" @default.
- W2067246066 hasPublicationYear "1996" @default.
- W2067246066 type Work @default.
- W2067246066 sameAs 2067246066 @default.
- W2067246066 citedByCount "92" @default.
- W2067246066 countsByYear W20672460662012 @default.
- W2067246066 countsByYear W20672460662013 @default.
- W2067246066 countsByYear W20672460662014 @default.
- W2067246066 countsByYear W20672460662015 @default.
- W2067246066 countsByYear W20672460662016 @default.
- W2067246066 countsByYear W20672460662017 @default.
- W2067246066 countsByYear W20672460662018 @default.
- W2067246066 countsByYear W20672460662019 @default.
- W2067246066 countsByYear W20672460662020 @default.
- W2067246066 countsByYear W20672460662021 @default.
- W2067246066 countsByYear W20672460662022 @default.
- W2067246066 crossrefType "journal-article" @default.
- W2067246066 hasAuthorship W2067246066A5031849699 @default.
- W2067246066 hasAuthorship W2067246066A5063835467 @default.
- W2067246066 hasConcept C121332964 @default.
- W2067246066 hasConcept C12554922 @default.
- W2067246066 hasConcept C185592680 @default.
- W2067246066 hasConcept C192157962 @default.
- W2067246066 hasConcept C2778163477 @default.
- W2067246066 hasConcept C41625074 @default.
- W2067246066 hasConcept C55493867 @default.
- W2067246066 hasConcept C62520636 @default.
- W2067246066 hasConcept C86803240 @default.
- W2067246066 hasConcept C91881484 @default.
- W2067246066 hasConceptScore W2067246066C121332964 @default.
- W2067246066 hasConceptScore W2067246066C12554922 @default.
- W2067246066 hasConceptScore W2067246066C185592680 @default.
- W2067246066 hasConceptScore W2067246066C192157962 @default.
- W2067246066 hasConceptScore W2067246066C2778163477 @default.
- W2067246066 hasConceptScore W2067246066C41625074 @default.
- W2067246066 hasConceptScore W2067246066C55493867 @default.
- W2067246066 hasConceptScore W2067246066C62520636 @default.
- W2067246066 hasConceptScore W2067246066C86803240 @default.
- W2067246066 hasConceptScore W2067246066C91881484 @default.
- W2067246066 hasIssue "4" @default.
- W2067246066 hasLocation W20672460661 @default.
- W2067246066 hasLocation W20672460662 @default.
- W2067246066 hasOpenAccess W2067246066 @default.
- W2067246066 hasPrimaryLocation W20672460661 @default.
- W2067246066 hasRelatedWork W1025998060 @default.
- W2067246066 hasRelatedWork W1995706914 @default.
- W2067246066 hasRelatedWork W2067246066 @default.
- W2067246066 hasRelatedWork W2155653247 @default.
- W2067246066 hasRelatedWork W2161536338 @default.
- W2067246066 hasRelatedWork W2169744378 @default.
- W2067246066 hasRelatedWork W2409248325 @default.
- W2067246066 hasRelatedWork W3030061171 @default.
- W2067246066 hasRelatedWork W3092932241 @default.
- W2067246066 hasRelatedWork W3207150890 @default.
- W2067246066 hasVolume "35" @default.
- W2067246066 isParatext "false" @default.
- W2067246066 isRetracted "false" @default.
- W2067246066 magId "2067246066" @default.
- W2067246066 workType "article" @default.