Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067247712> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2067247712 endingPage "754" @default.
- W2067247712 startingPage "747" @default.
- W2067247712 abstract "Cross-resistance presents an obstacle in cancer chemotherapy. Cadmium is a potential carcinogen whose exposure has been shown in epidemiological and laboratory experiments to cause lung cancer. Cadmium also induces various forms of resistance in human lung carcinoma cells. This resistance may be shared by antineoplastic agents, which should be a concern for chemotherapy of cadmium-induced lung cancer. In the present study, two subpopulations of human lung carcinoma A549 cells with a different magnitude of resistance to cadmium coxicity were shown to have a parallel resistance to the cytotoxic action of Adriamycin (ADR), an important anticancer drug. Several factors were examined to investigate the mechanism(s) for the cross-resistance, including cellular metallothionein and glutathione (GSH) concentrations, glutathione S-transferase activity, mdr1 expression, and antioxidant enzyme activities including superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Only cellular GSH content was elevated consistently in the cadmium/ADR-resistant cells relative to the cadmium/ADR-sensitive cells. Treatment with buthionine sulfoximine, a specific inhibitor of GSH synthesis sensitized both cell lines to ADR only when the cellular GSH levels were depleted to about 5% of control. This BSO treatment, however, did not affect cell viability. Further study revealed that the cadmium/ADR-resistant cells have a greater capacity in recovery of cellular GSH content following BSO treatment. The results demonstrate that cross-resistance to ADR exists in cadmium-resistant human lung carcinoma A549 cells, and enhanced GSH synthesis capacity, rather than elevated levels of cellular GSH, may be related to this resistance." @default.
- W2067247712 created "2016-06-24" @default.
- W2067247712 creator A5016685100 @default.
- W2067247712 creator A5018089139 @default.
- W2067247712 creator A5026799694 @default.
- W2067247712 date "1997-03-01" @default.
- W2067247712 modified "2023-09-24" @default.
- W2067247712 title "Decreased sensitivity to adriamycin in cadmium-resistant human lung carcinoma A549 cells" @default.
- W2067247712 cites W1538763799 @default.
- W2067247712 cites W1546592314 @default.
- W2067247712 cites W1581414347 @default.
- W2067247712 cites W1601942384 @default.
- W2067247712 cites W1664552158 @default.
- W2067247712 cites W191793640 @default.
- W2067247712 cites W1969931373 @default.
- W2067247712 cites W1978656978 @default.
- W2067247712 cites W1979029158 @default.
- W2067247712 cites W1980390665 @default.
- W2067247712 cites W1983232483 @default.
- W2067247712 cites W1984017142 @default.
- W2067247712 cites W1990755444 @default.
- W2067247712 cites W2007064404 @default.
- W2067247712 cites W2014669590 @default.
- W2067247712 cites W2039042657 @default.
- W2067247712 cites W2071048307 @default.
- W2067247712 cites W2072687304 @default.
- W2067247712 cites W2079508025 @default.
- W2067247712 cites W2081981245 @default.
- W2067247712 cites W2085076521 @default.
- W2067247712 cites W2120114097 @default.
- W2067247712 cites W2126315184 @default.
- W2067247712 cites W2159305277 @default.
- W2067247712 cites W2197332903 @default.
- W2067247712 cites W4232534952 @default.
- W2067247712 doi "https://doi.org/10.1016/s0006-2952(96)00811-8" @default.
- W2067247712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9113095" @default.
- W2067247712 hasPublicationYear "1997" @default.
- W2067247712 type Work @default.
- W2067247712 sameAs 2067247712 @default.
- W2067247712 citedByCount "12" @default.
- W2067247712 countsByYear W20672477122014 @default.
- W2067247712 countsByYear W20672477122016 @default.
- W2067247712 crossrefType "journal-article" @default.
- W2067247712 hasAuthorship W2067247712A5016685100 @default.
- W2067247712 hasAuthorship W2067247712A5018089139 @default.
- W2067247712 hasAuthorship W2067247712A5026799694 @default.
- W2067247712 hasConcept C1491633281 @default.
- W2067247712 hasConcept C165069038 @default.
- W2067247712 hasConcept C178790620 @default.
- W2067247712 hasConcept C181199279 @default.
- W2067247712 hasConcept C185592680 @default.
- W2067247712 hasConcept C2775838275 @default.
- W2067247712 hasConcept C2777476445 @default.
- W2067247712 hasConcept C2778004101 @default.
- W2067247712 hasConcept C2778760513 @default.
- W2067247712 hasConcept C502942594 @default.
- W2067247712 hasConcept C538909803 @default.
- W2067247712 hasConcept C544657597 @default.
- W2067247712 hasConcept C55493867 @default.
- W2067247712 hasConcept C81729549 @default.
- W2067247712 hasConcept C86803240 @default.
- W2067247712 hasConcept C98274493 @default.
- W2067247712 hasConceptScore W2067247712C1491633281 @default.
- W2067247712 hasConceptScore W2067247712C165069038 @default.
- W2067247712 hasConceptScore W2067247712C178790620 @default.
- W2067247712 hasConceptScore W2067247712C181199279 @default.
- W2067247712 hasConceptScore W2067247712C185592680 @default.
- W2067247712 hasConceptScore W2067247712C2775838275 @default.
- W2067247712 hasConceptScore W2067247712C2777476445 @default.
- W2067247712 hasConceptScore W2067247712C2778004101 @default.
- W2067247712 hasConceptScore W2067247712C2778760513 @default.
- W2067247712 hasConceptScore W2067247712C502942594 @default.
- W2067247712 hasConceptScore W2067247712C538909803 @default.
- W2067247712 hasConceptScore W2067247712C544657597 @default.
- W2067247712 hasConceptScore W2067247712C55493867 @default.
- W2067247712 hasConceptScore W2067247712C81729549 @default.
- W2067247712 hasConceptScore W2067247712C86803240 @default.
- W2067247712 hasConceptScore W2067247712C98274493 @default.
- W2067247712 hasIssue "5" @default.
- W2067247712 hasLocation W20672477121 @default.
- W2067247712 hasLocation W20672477122 @default.
- W2067247712 hasOpenAccess W2067247712 @default.
- W2067247712 hasPrimaryLocation W20672477121 @default.
- W2067247712 hasRelatedWork W159419932 @default.
- W2067247712 hasRelatedWork W1994127376 @default.
- W2067247712 hasRelatedWork W2028140738 @default.
- W2067247712 hasRelatedWork W2111284905 @default.
- W2067247712 hasRelatedWork W2321281833 @default.
- W2067247712 hasRelatedWork W2375140672 @default.
- W2067247712 hasRelatedWork W2522126840 @default.
- W2067247712 hasRelatedWork W2891721693 @default.
- W2067247712 hasRelatedWork W3004034935 @default.
- W2067247712 hasRelatedWork W88841968 @default.
- W2067247712 hasVolume "53" @default.
- W2067247712 isParatext "false" @default.
- W2067247712 isRetracted "false" @default.
- W2067247712 magId "2067247712" @default.
- W2067247712 workType "article" @default.