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- W2067278327 abstract "One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory has been developed for binary systems. The aim of this work is to study for the first time the existence and behaviour of the percolation thresholds in ternary pharmaceutical tablets. For this purpose, mixtures containing three substances with very different hydrophilicity and water-solubility—KCl, polyvinylpyrrolidone cross-linked (PVP-CL) and Eudragit® RS-PM—were prepared and compressed. The bulk and tapped densities of the mixtures as well as the hardness and in-vitro release behaviour of the tablets have been studied. The KCl percolation threshold has been estimated in the range 0.26–0.31 of total porosity. A range where PVP-CL percolates can be defined between 10 and 30% v/v. This influences the hardness of the tablet. On the other hand, the existence of a ‘combined percolation threshold’ of the sum of all the hydrophilic substances, i.e. KCl and PVP-CL, has been found at 35% v/v approximately. This fact is in agreement with previous results." @default.
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- W2067278327 date "1996-08-01" @default.
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- W2067278327 title "Study of percolation thresholds in ternary tablets" @default.
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- W2067278327 doi "https://doi.org/10.1016/0378-5173(96)04603-0" @default.
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