FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067278409> ?p ?o ?g. }

• W2067278409 endingPage "11" @default.
• W2067278409 startingPage "1" @default.
• W2067278409 abstract "The tumorigenesis of gastrointestinal and pancreatic tumors (GEPNETs) is poorly understood. We need a better understanding of the molecular alterations in GEPNETs to obtain an accurate classification, and it may also provide targets for therapeutic intervention. Purpose of Paper . The purpose of this paper was to critically examine recent advances in the molecular understanding of GEPNETs gained from genome-wide and transcriptome-wide profiling studies. Special emphasis was put on diagnostic, predictive, and therapeutic implications of profiling studies. Results . Pancreatic neuroendocrine tumours (PNETs) were characterised by a distinct pattern of chromosomal alterations and a higher degree of chromosomal instability (CIN) than ileal carcinoids. Subgroups of PNETs and ileal carcinoids were identified on the basis of specific chromosomal alterations. Exome sequencing identified mutations in MEN1, ATRX/DAXX , and mTOR pathway genes as being frequent events in sporadic PNETs. Expression profiles of PNETs and ileal carcinoids were found to be different, and allowed identification of subgroups of tumors, as well discrimination between benign and malignant tumors. The molecular data provided a number of candidate genes and pathways suitable for targeted therapy. For PNETs, candidate targets include BRAF, KRAS, TERT, EGFR, RET, MDM2, IGF, MET/HGF, ANG2, LCK, PDGFRB, AKT-mTOR, and SSTR2. Some of these targets have already been evaluated in clinical trials (mTOR and SSTR2). For ileal carcinoids, significantly fewer candidate targets were provided, including ERBB2 (HER2), RET, APLP1, and Notch. Conclusion . Profiling of GEPNETs is a powerful tool for discovery of novel targets for therapeutic intervention. Further studies, combining genome, epigenome, transcriptome, and proteome data are needed to enable us to identify clinically relevant targets in GEPNETs." @default.
• W2067278409 created "2016-06-24" @default.
• W2067278409 creator A5056070577 @default.
• W2067278409 date "2012-02-29" @default.
• W2067278409 modified "2023-10-16" @default.
• W2067278409 title "Profiling of GEPNETs" @default.
• W2067278409 cites W1964821219 @default.
• W2067278409 cites W1965856472 @default.
• W2067278409 cites W1970675874 @default.
• W2067278409 cites W1971349452 @default.
• W2067278409 cites W1973939581 @default.
• W2067278409 cites W1974192919 @default.
• W2067278409 cites W1986009297 @default.
• W2067278409 cites W1986482998 @default.
• W2067278409 cites W1990184567 @default.
• W2067278409 cites W1997978066 @default.
• W2067278409 cites W2000392923 @default.
• W2067278409 cites W2005250386 @default.
• W2067278409 cites W2010381759 @default.
• W2067278409 cites W2021213817 @default.
• W2067278409 cites W2021790986 @default.
• W2067278409 cites W2025930851 @default.
• W2067278409 cites W2036852888 @default.
• W2067278409 cites W2041181609 @default.
• W2067278409 cites W2042148986 @default.
• W2067278409 cites W2043729877 @default.
• W2067278409 cites W2055085803 @default.
• W2067278409 cites W2065494273 @default.
• W2067278409 cites W2067398230 @default.
• W2067278409 cites W2068555261 @default.
• W2067278409 cites W2070392475 @default.
• W2067278409 cites W2070563494 @default.
• W2067278409 cites W2071003875 @default.
• W2067278409 cites W2074455613 @default.
• W2067278409 cites W2074867245 @default.
• W2067278409 cites W2075975440 @default.
• W2067278409 cites W2078438113 @default.
• W2067278409 cites W2082310013 @default.
• W2067278409 cites W2083122376 @default.
• W2067278409 cites W2084897180 @default.
• W2067278409 cites W2090388010 @default.
• W2067278409 cites W2092624752 @default.
• W2067278409 cites W2093456980 @default.
• W2067278409 cites W2094629870 @default.
• W2067278409 cites W2097933346 @default.
• W2067278409 cites W2099782348 @default.
• W2067278409 cites W2100171549 @default.
• W2067278409 cites W2100878516 @default.
• W2067278409 cites W2100945326 @default.
• W2067278409 cites W2106543129 @default.
• W2067278409 cites W2108721215 @default.
• W2067278409 cites W2110922803 @default.
• W2067278409 cites W2112064092 @default.
• W2067278409 cites W2115686439 @default.
• W2067278409 cites W2120960711 @default.
• W2067278409 cites W2123623100 @default.
• W2067278409 cites W2123753402 @default.
• W2067278409 cites W2128986947 @default.
• W2067278409 cites W2130162829 @default.
• W2067278409 cites W2140766252 @default.
• W2067278409 cites W2143387575 @default.
• W2067278409 cites W2145070131 @default.
• W2067278409 cites W2145258806 @default.
• W2067278409 cites W2145441158 @default.
• W2067278409 cites W2147545245 @default.
• W2067278409 cites W2148747232 @default.
• W2067278409 cites W2149214723 @default.
• W2067278409 cites W2151067616 @default.
• W2067278409 cites W2152485190 @default.
• W2067278409 cites W2155249652 @default.
• W2067278409 cites W2157212789 @default.
• W2067278409 cites W2157320520 @default.
• W2067278409 cites W2160531384 @default.
• W2067278409 cites W2170259414 @default.
• W2067278409 cites W2171201030 @default.
• W2067278409 doi "https://doi.org/10.5402/2012/874350" @default.
• W2067278409 hasPublicationYear "2012" @default.
• W2067278409 type Work @default.
• W2067278409 sameAs 2067278409 @default.
• W2067278409 citedByCount "0" @default.
• W2067278409 crossrefType "journal-article" @default.
• W2067278409 hasAuthorship W2067278409A5056070577 @default.
• W2067278409 hasBestOaLocation W20672784091 @default.
• W2067278409 hasConcept C104317684 @default.
• W2067278409 hasConcept C1167327 @default.
• W2067278409 hasConcept C121608353 @default.
• W2067278409 hasConcept C127716648 @default.
• W2067278409 hasConcept C134018914 @default.
• W2067278409 hasConcept C150194340 @default.
• W2067278409 hasConcept C162317418 @default.
• W2067278409 hasConcept C16671776 @default.
• W2067278409 hasConcept C18431079 @default.
• W2067278409 hasConcept C2779066768 @default.
• W2067278409 hasConcept C2779469564 @default.
• W2067278409 hasConcept C2780103800 @default.
• W2067278409 hasConcept C2780265364 @default.
• W2067278409 hasConcept C2781187634 @default.
• W2067278409 hasConcept C502942594 @default.

• next